The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently
discovered member of the opioid receptor family and, together with its endogenous ligand …

Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Buprenorphine, an opioid with mixed agonist-antagonist activity at classical opioid
receptors, has been approved recently for the treatment of opioid dependency …

The isolation of an opioid receptor-related clone soon led to the isolation and
characterization of a new neuropeptide, termed orphanin FQ or nociceptin (OFQ/N). This …

Nociceptin (NC), alias Orphanin FQ, has been recently identified as the endogenous ligand
of the opioid receptor‐like 1 receptor (OP4). This new NC/OP4 receptor system belongs to …

Orphanin FQ (OFQ) is the endogenous agonist of the opioid receptor‐like receptor (ORL‐1).
It and its precursor, prepro‐OFQ, exhibit structural features suggestive of the opioid peptides …

The recently discovered neuropeptide orphanin FQ (OFQ), and its opioid receptor‐like
(ORL1) receptor, exhibit structural features suggestive of the μ, κ, and δ opioid systems. The …

The ORL1 receptor is a G protein-coupled receptor structurally related to the opioid
receptors, whose endogenous ligand is the heptadecapeptide nociceptin/orphanin FQ. In …

The publication of the δ opioid receptor sequence led to the cloning of three homologous
receptors: the μ and κ opioid receptors, and a novel opioid-like orphan receptor. The orphan …