Dietary flavonoids: Cardioprotective potential with antioxidant effects and their pharmacokinetic, toxicological and therapeutic concerns
Flavonoids comprise a large group of structurally diverse polyphenolic compounds of plant
origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy …
origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy …
Autophagy and cardiac diseases: Therapeutic potential of natural products
The global incidence of cardiac diseases is expected to increase in the coming years,
imposing a substantial socioeconomic burden on healthcare systems. Autophagy is a tightly …
imposing a substantial socioeconomic burden on healthcare systems. Autophagy is a tightly …
[HTML][HTML] Exosomes derived from mesenchymal stem cells rescue myocardial ischaemia/reperfusion injury by inducing cardiomyocyte autophagy via AMPK and Akt …
L Liu, X **, CF Hu, R Li, Z Zhou… - Cellular physiology and …, 2017 - karger.com
Background/Aims: Reperfusion after an ischaemic insult might cause infarct extension.
Mesenchymal stem cell (MSC)-derived exosomes could attenuate myocardial remodelling in …
Mesenchymal stem cell (MSC)-derived exosomes could attenuate myocardial remodelling in …
Regulation of autophagy of the heart in ischemia and reperfusion
SV Popov, AV Mukhomedzyanov, NS Voronkov… - Apoptosis, 2023 - Springer
Abstract Ischemia/reperfusion (I/R) of the heart leads to increased autophagic flux.
Preconditioning stimulates autophagic flux by AMPK and PI3-kinase activation and mTOR …
Preconditioning stimulates autophagic flux by AMPK and PI3-kinase activation and mTOR …
Resveratrol reestablishes mitochondrial quality control in myocardial ischemia/reperfusion injury through Sirt1/Sirt3-Mfn2-Parkin-PGC-1α pathway
M Zheng, Y Bai, X Sun, R Fu, L Liu, M Liu, Z Li… - Molecules, 2022 - mdpi.com
Resveratrol is a natural polyphenol found in various plants. It has been widely studied on
cardiovascular disorders. It is known that resveratrol can activate Sirtuin proteins and …
cardiovascular disorders. It is known that resveratrol can activate Sirtuin proteins and …
Natural drugs as a treatment strategy for cardiovascular disease through the regulation of oxidative stress
X Chang, T Zhang, W Zhang, Z Zhao… - Oxidative Medicine and …, 2020 - Wiley Online Library
Oxidative stress (OS) refers to the physiological imbalance between oxidative and
antioxidative processes leading to increased oxidation, which then results in the …
antioxidative processes leading to increased oxidation, which then results in the …
Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus …
Z Zhang, J Wu, C Teng, J Wang, J Yu, C **, L Wang… - Apoptosis, 2022 - Springer
Although considered as a major contributor to low back pain (LBP), intervertebral disc
degeneration (IVDD) has poor medical and surgical treatments. Various studies have …
degeneration (IVDD) has poor medical and surgical treatments. Various studies have …
Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside
Diabetic patients are at an increased risk of develo** heart failure when compared to their
non-diabetic counter parts. Accumulative evidence suggests chronic hyperglycemia to be …
non-diabetic counter parts. Accumulative evidence suggests chronic hyperglycemia to be …
Promising therapeutic candidate for myocardial ischemia/reperfusion injury: what are the possible mechanisms and roles of phytochemicals?
C Chen, LT Yu, BR Cheng, JL Xu, Y Cai… - Frontiers in …, 2022 - frontiersin.org
Percutaneous coronary intervention (PCI) is one of the most effective reperfusion strategies
for acute myocardial infarction (AMI) despite myocardial ischemia/reperfusion (I/R) injury …
for acute myocardial infarction (AMI) despite myocardial ischemia/reperfusion (I/R) injury …
MicroRNA-384-5p/Beclin-1 as potential indicators for epigallocatechin gallate against cardiomyocytes ischemia reperfusion injury by inhibiting autophagy via PI3K/Akt …
C Zhang, R Liang, X Gan, X Yang… - Drug Design …, 2019 - Taylor & Francis
Background/Aims Epigallocatechin gallate (EGCG) has established protective actions
against myocardial ischemia/reperfusion (I/R) injury by regulating autophagy. However, little …
against myocardial ischemia/reperfusion (I/R) injury by regulating autophagy. However, little …