Abstract 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts the inactive
glucocorticoid cortisone and its active form cortisol. It is widely expressed and, although …

Metabolic syndrome is a prevalent condition in adults over the age of 65 and is a risk factor
for develo** cardiovascular disease and type II diabetes. Thus, methods to track the …

Despite the well-documented association between insulin resistance and cardiovascular
disease, the key targets of insulin relevant to the development of cardiovascular disease are …

Hormones such as fibroblast growth factor 21 (FGF21) and glucocorticoids (GCs) play
crucial roles in coordinating the adaptive starvation response. Here we examine the …

The gynecological disease endometriosis is characterized by the deposition and
proliferation of endometrial cells outside the uterus and clinically is linked to low body mass …

Hepatocellular carcinoma (HCC) occurs more frequently and aggressively in men than
women, but the mechanistic basis of this gender disparity is obscure. Chronic inflammation …

Functional hypercortisolism (FH) is caused by conditions able to chronically activate
hypothalamic–pituitary–adrenal axis and usually occurs in cases of major depression …

Cushing's syndrome, caused by increased production of cortisol, leads to metabolic
dysfunction including visceral adiposity, hypertension, hyperlipidaemia and type 2 diabetes …

Context: Tissue cortisol exposure is under the control of the isozymes of 11β-hydroxysteroid
dehydrogenase (11β-HSD). 11β-HSD1 in vivo, acts as an oxoreductase converting inactive …

Abstract Aims Fluorene-9-bisphenol (BHPF), as a substitute for bisphenol A, is used in many
industries in daily life. Many studies have clarified its effects as an endocrine disruptor on …