Neural circuit mechanisms of social behavior

P Chen, W Hong - Neuron, 2018 - cell.com
We live in a world that is largely socially constructed, and we are constantly involved in and
fundamentally influenced by a broad array of complex social interactions. Social behaviors …

VTA GABA neurons at the interface of stress and reward

C Bouarab, B Thompson, AM Polter - Frontiers in neural circuits, 2019 - frontiersin.org
The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to
forebrain regions and their critical role in regulating reward, motivation, cognition, and …

Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region

JR Moffitt, D Bambah-Mukku, SW Eichhorn, E Vaughn… - Science, 2018 - science.org
INTRODUCTION A mechanistic understanding of brain function requires the identification of
distinct cell types in the brain at a molecular, spatial, and functional level. The preoptic …

An amygdala-to-hypothalamus circuit for social reward

RK Hu, Y Zuo, T Ly, J Wang, P Meera, YE Wu… - Nature …, 2021 - nature.com
Social interactions and relationships are often rewarding, but the neural mechanisms
through which social interaction drives positive experience remain poorly understood. In this …

Functional circuit architecture underlying parental behaviour

J Kohl, BM Babayan, ND Rubinstein, AE Autry… - Nature, 2018 - nature.com
Parenting is essential for the survival and wellbeing of mammalian offspring. However, we
lack a circuit-level understanding of how distinct components of this behaviour are …

The medial preoptic area mediates depressive-like behaviors induced by ovarian hormone withdrawal through distinct GABAergic projections

C Tao, GW Zhang, JJ Huang, Z Li, HW Tao… - Nature …, 2023 - nature.com
Fluctuations in reproductive hormone levels are associated with mood disruptions in
women, such as in postpartum and perimenopausal depression. However, the neural circuit …

[HTML][HTML] Multimodal analysis of cell types in a hypothalamic node controlling social behavior

DW Kim, Z Yao, LT Graybuck, TK Kim, TN Nguyen… - Cell, 2019 - cell.com
The ventrolateral subdivision of the ventromedial hypothalamus (VMHvl) contains∼ 4,000
neurons that project to multiple targets and control innate social behaviors including …

Hypothalamic dopamine neurons motivate mating through persistent cAMP signalling

SX Zhang, A Lutas, S Yang, A Diaz, H Fluhr, G Nagel… - Nature, 2021 - nature.com
Transient neuromodulation can have long-lasting effects on neural circuits and motivational
states,,–. Here we examine the dopaminergic mechanisms that underlie mating drive and its …

Sex differences and the neurobiology of affective disorders

DR Rubinow, PJ Schmidt - Neuropsychopharmacology, 2019 - nature.com
Observations of the disproportionate incidence of depression in women compared with men
have long preceded the recent explosion of interest in sex differences. Nonetheless, the …

[PDF][PDF] A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior

JR Knoedler, S Inoue, DW Bayless, T Yang, A Tantry… - Cell, 2022 - cell.com
Sex hormones exert a profound influence on gendered behaviors. How individual sex
hormone-responsive neuronal populations regulate diverse sex-typical behaviors is unclear …