Dihydrofolate reductase, thymidylate synthase, and serine hydroxy methyltransferase: successful targets against some infectious diseases
H Shamshad, R Bakri, AZ Mirza - Molecular Biology Reports, 2022 - Springer
Parasitic diseases have a serious impact on the world in terms of health and economics and
are responsible for worldwide mortality and morbidity. The present review features the …
are responsible for worldwide mortality and morbidity. The present review features the …
A comprehensive review on synthetic approach for antimalarial agents
Malaria has emerged as a major health problem worldwide after the appearance of resistant
strains of Plasmodium falciparum to the most of antimalarial drugs. The development of …
strains of Plasmodium falciparum to the most of antimalarial drugs. The development of …
Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity
A class of hybrid molecules consisting of 4-aminoquinoline and pyrimidine were synthesized
and tested for antimalarial activity against both chloroquine (CQ)-sensitive (D6) and …
and tested for antimalarial activity against both chloroquine (CQ)-sensitive (D6) and …
Addition of thiols to o-quinone methide: new 2-hydroxy-3-phenylsulfanylmethyl [1, 4] naphthoquinones and their activity against the human malaria parasite …
A series of 36 new phenylsulfanylmethyl [1, 4] naphthoquinones (7–42) were synthesized by
a three-component reaction that involves lawsone, the appropriate aldehyde and thiols with …
a three-component reaction that involves lawsone, the appropriate aldehyde and thiols with …
Sulfonamide based pyrimidine derivatives combating Plasmodium parasite by inhibiting falcipains-2 and falcipains-3 as antimalarial agents
In this report, we present the design and synthesis of a novel series of pyrimidine-tethered
spirochromane-based sulfonamide derivatives aimed at combating drug resistance in …
spirochromane-based sulfonamide derivatives aimed at combating drug resistance in …
[HTML][HTML] Malária: aspectos históricos e quimioterapia
TCC França, MG Santos, JD Figueroa-Villar - Química Nova, 2008 - SciELO Brasil
Malaria is still a very serious worldwide public health problem affecting between 300 and
500 million people and causing from 1.0 to 2.5 million deaths annually. The major problems …
500 million people and causing from 1.0 to 2.5 million deaths annually. The major problems …
Genetic Transformation of Artemisia carvifolia Buch with rol Genes Enhances Artemisinin Accumulation
The potent antimalarial drug artemisinin has a high cost, since its only viable source to date
is Artemisia annua (0.01–0.8% DW). There is therefore an urgent need to design new …
is Artemisia annua (0.01–0.8% DW). There is therefore an urgent need to design new …
Computer-aided molecular design of 1H-imidazole-2,4-diamine derivatives as potential inhibitors of Plasmodium falciparum DHFR enzyme
Abstract Design and discovery of new potential inhibitors of Plasmodium falciparum
dihydrofolate reductase (PfDHFR), equally active against both the wild-type and mutant …
dihydrofolate reductase (PfDHFR), equally active against both the wild-type and mutant …
[HTML][HTML] New approaches to the development of anti-protozoan drug candidates: a review of patents
Protozoan infections are parasitic diseases that affect hundreds of millions of people
worldwide, but have been largely neglected for drug development because they affect poor …
worldwide, but have been largely neglected for drug development because they affect poor …
Antimalarial chemotherapy, mechanisms of action and resistance to major antimalarial drugs in clinical use: A Review
AM Daskum, G Chessed, MA Qadeer… - Microbes and …, 2021 - mid.journals.ekb.eg
Malaria has remained the leading cause of death in children under five years of age and
pregnant women in sub-Saharan Africa and other endemic countries. The discoveries of …
pregnant women in sub-Saharan Africa and other endemic countries. The discoveries of …