Background Cancer is characterized by the rampant proliferation, growth, and infiltration of
malignantly transformed cancer cells past their normal boundaries into adjacent tissues. It is …

The use of artificial intelligence will transform clinical practice over the next decade and the
early impact of this will likely be the integration of image analysis and machine learning into …

Standardized benchmarking approaches are required to assess the accuracy of variants
called from sequence data. Although variant-calling tools and the metrics used to assess …

Next-generation sequencing technologies have been and continue to be deployed in
clinical laboratories, enabling rapid transformations in genomic medicine. These …

Next-generation sequencing (NGS) technologies are now established in clinical laboratories
as a primary testing modality in genomic medicine. These technologies have reduced the …

In chronic lymphocytic leukemia (CLL), analysis of TP53 aberrations (deletion and/or
mutation) is a crucial part of treatment decision-making algorithms. Technological and …

This document was developed by the Pharmacogenomics (PGx) Working Group of the
Association for Molecular Pathology Clinical Practice Committee, whose aim is to …

Context The higher throughput and lower per-base cost of next-generation sequencing
(NGS) as compared to Sanger sequencing has led to its rapid adoption in clinical testing …

Inherited loss-of-function mutations in the tumor suppressor genes BRCA1, BRCA2, and
multiple other genes predispose to high risks of breast and/or ovarian cancer. Cancer …

The progressive elucidation of the molecular pathogenesis of cancer has fueled the rational
development of targeted drugs for patient populations stratified by genetic characteristics …