Design of hydrogel-based scaffolds for the treatment of spinal cord injuries

N Ghane, MH Beigi, S Labbaf… - Journal of Materials …, 2020 - pubs.rsc.org
Spinal cord injury (SCI) is a traumatic lesion that diminishes sensory and/or motor neuronal
functionality, directly affecting the quality of the patient's life. Due to the central nervous …

Experimental spinal cord injury and behavioral tests in laboratory rats

RU Ahmed, M Alam, YP Zheng - Heliyon, 2019 - cell.com
Traumatic spinal cord injury (SCI) results in some serious neurophysiological consequences
that alter healthy body functions and devastate the quality of living of individuals. To find a …

Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats

X Wang, X Li, X Zuo, Z Liang, T Ding, K Li, Y Ma… - Journal of …, 2021 - Springer
Background Neurotoxic microglia and astrocytes begin to activate and participate in
pathological processes after spinal cord injury (SCI), subsequently causing severe …

Engineered Macrophage Membrane‐Coated Nanoparticles with Enhanced CCR2 Expression Promote Spinal Cord Injury Repair by Suppressing Neuroinflammation …

C Gu, X Geng, Y Wu, Y Dai, J Zeng, Z Wang, H Fang… - Small, 2024 - Wiley Online Library
Spinal cord injury (SCI) is a severe neurological disorder characterized by significant
disability and limited treatment options. Mitigating the secondary inflammatory response …

Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury

F Jiang, M **a, Y Zhang, J Chang, J Cao… - Frontiers in …, 2022 - frontiersin.org
Background Neuroinflammation following spinal cord injury (SCI) results in prolonged
neurological damage and locomotor dysfunction. Polarization of microglia is vital to …

Growth differentiation factor 15 regulates oxidative stress-dependent ferroptosis post spinal cord injury by stabilizing the p62-Keap1-Nrf2 signaling pathway

M **a, Q Zhang, Y Zhang, R Li, T Zhao… - Frontiers in Aging …, 2022 - frontiersin.org
Background Spinal cord injury (SCI) is a severe traumatic disorder of the central nervous
system (CNS) that causes irreversible damage to the nervous tissue. The consequent …

[HTML][HTML] Alpha-tocopherol inhibits ferroptosis and promotes neural function recovery in rats with spinal cord injury via downregulating Alox15

R Zhu, Y Kang, Q Li, K Peng, X Shi, Z Yin… - Biomedicine & …, 2024 - Elsevier
Spinal cord injury (SCI) is a type of central nervous system (CNS) injury in which ferroptosis
is becoming a promising target for treatment. Alpha-tocopherol (Vitamin E, Vit E) is a …

Long-Acting Heterodimeric Paclitaxel–Idebenone Prodrug-Based Nanomedicine Promotes Functional Recovery after Spinal Cord Injury

Z Xu, X Liu, Y Pang, Z Chen, Y Jiang, T Liu, J Zhang… - Nano Letters, 2024 - ACS Publications
After spinal cord injury (SCI), successive systemic administration of microtubule-stabilizing
agents has been shown to promote axon regeneration. However, this approach is limited by …

[HTML][HTML] Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage …

J Xu, C Shi, F Yuan, Y Ding, Y **e, Y Liu, F Zhu, H Lu… - Bioactive Materials, 2024 - Elsevier
Mitochondria are crucial in sustaining and orchestrating cellular functions. Capitalizing on
this, we explored mitochondrial transplantation as an innovative therapeutic strategy for …

Multifunctional hierarchical nanoplatform with anisotropic bimodal mesopores for effective neural circuit reconstruction after spinal cord injury

F Kong, H Yu, L Gao, E **ng, Y Yu, X Sun, W Wang… - ACS …, 2024 - ACS Publications
A persistent inflammatory response, intrinsic limitations in axonal regenerative capacity, and
widespread presence of extrinsic axonal inhibitors impede the restoration of motor function …