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Mechanisms and treatment of pulmonary arterial hypertension
Substantial progress has been made in the management of pulmonary arterial hypertension
(PAH) in the past 25 years, but the disease remains life-limiting. Established therapies for …
(PAH) in the past 25 years, but the disease remains life-limiting. Established therapies for …
[HTML][HTML] The functional cross talk between cancer cells and cancer associated fibroblasts from a cancer mechanics perspective
The function of biological tissues in health and disease is regulated at cellular level and is
highly influenced by the physical microenvironment, through the interaction of forces …
highly influenced by the physical microenvironment, through the interaction of forces …
[HTML][HTML] Sodium glucose co-transporter 2 inhibitors ameliorate endothelium barrier dysfunction induced by cyclic stretch through inhibition of reactive oxygen species
SGLT-2i's exert direct anti-inflammatory and anti-oxidative effects on resting endothelial
cells. However, endothelial cells are constantly exposed to mechanical forces such as cyclic …
cells. However, endothelial cells are constantly exposed to mechanical forces such as cyclic …
Biomechanical and mechanobiological drivers of the transition from postcapillary pulmonary hypertension to combined pre−/postcapillary pulmonary hypertension
BJ Allen, H Frye, R Ramanathan… - Journal of the …, 2023 - ahajournals.org
Combined pre−/postcapillary pulmonary hypertension (Cpc‐PH), a complication of left heart
failure, is associated with higher mortality rates than isolated postcapillary pulmonary …
failure, is associated with higher mortality rates than isolated postcapillary pulmonary …
A comparison of Newtonian and non-Newtonian pulsatile blood rheology in carotid bifurcation through fluid–solid interaction hemodynamic assessment based on …
Endothelial cells play a crucial role in the arterial homeostasis. In addition to physiological
risk factors, abnormal levels of hemodynamic parameters induced by the pulsatile flow …
risk factors, abnormal levels of hemodynamic parameters induced by the pulsatile flow …
Multiscale mechanobiology: Coupling models of adhesion kinetics and nonlinear tissue mechanics
The mechanical behavior of tissues at the macroscale is tightly coupled to cellular activity at
the microscale. Dermal wound healing is a prominent example of a complex system in which …
the microscale. Dermal wound healing is a prominent example of a complex system in which …
[HTML][HTML] Stretch-induced damage in endothelial monolayers
Y Choi, R Jakob, AE Ehret, L von Bohemer… - Biomaterials …, 2024 - Elsevier
Endothelial cells are constantly exposed to mechanical stimuli, of which mechanical stretch
has shown various beneficial or deleterious effects depending on whether loads are within …
has shown various beneficial or deleterious effects depending on whether loads are within …
Live endothelial cells on plasma-nitrided and oxidized titanium: An approach for evaluating biocompatibility
We evaluated the effects of titanium plasma nitriding and oxidation on live endothelial cell
viscoelasticity. For this, mechanically polished titanium surfaces and two surfaces treated by …
viscoelasticity. For this, mechanically polished titanium surfaces and two surfaces treated by …
The microenvironment and cytoskeletal remodeling in tumor cell invasion
The physical cues of tumor microenvironment (TME) contribute greatly to the initiation and
progression of cancer. Tumor tissues usually become stiffer than healthy tissues with more …
progression of cancer. Tumor tissues usually become stiffer than healthy tissues with more …
Effects of the sodium-glucose cotransporter 2 inhibitors Canagliflozin, Dapagliflozin and Empagliflozin on endothelial barrier dysfunction: An in-vitro study
G Römer - 2023 - macau.uni-kiel.de
Cardiovascular diseases (CVDs) are by far the leading cause of death around the world. In
2015 CVDs were responsible for 31% of all global deaths, representing a total of estimated …
2015 CVDs were responsible for 31% of all global deaths, representing a total of estimated …