Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Anti-inflammatory targets for the treatment of reperfusion injury in stroke

A Mizuma, MA Yenari - Frontiers in neurology, 2017 - frontiersin.org
While the mainstay of acute stroke treatment includes revascularization via recombinant
tissue plasminogen activator or mechanical thrombectomy, only a minority of stroke patients …

Neuroprotection for ischaemic stroke: current status and challenges

A Moretti, F Ferrari, RF Villa - Pharmacology & therapeutics, 2015 - Elsevier
Stroke is the third cause of death worldwide and the main cause of chronic, severe adult
disability. We focus on acute ischaemic stroke, which accounts for approximately 80% of all …

[HTML][HTML] Lower-dose prescribing: minimizing “side effects” of pharmaceuticals on society and the environment

CG Daughton, IS Ruhoy - Science of the total Environment, 2013 - Elsevier
The prescribed use of pharmaceuticals can result in unintended, unwelcomed, and
potentially adverse consequences for the environment and for those not initially targeted for …

Neurovascular inflammation and complications of thrombolysis therapy in stroke

Q Liu, K Shi, Y Wang, FD Shi - Stroke, 2023 - Am Heart Assoc
Intravenous thrombolysis via tPA (tissue-type plasminogen activator) is the only approved
pharmacological treatment for acute ischemic stroke, but its benefits are limited by …

Research progress in stroke-induced immunodepression syndrome (SIDS) and stroke-associated pneumonia (SAP)

DD Liu, SF Chu, C Chen, PF Yang, NH Chen… - Neurochemistry …, 2018 - Elsevier
In recent years, stroke-induced immunodepression syndrome (SIDS) and the resulting
stroke-associated infection (SAI) have become a focus of current research efforts …

Refocusing neuroprotection in cerebral reperfusion era: new challenges and strategies

XY **ong, L Liu, QW Yang - Frontiers in neurology, 2018 - frontiersin.org
Pathophysiological processes of stroke have revealed that the damaged brain should be
considered as an integral structure to be protected. However, promising neuroprotective …

Neuroprotective effects of coenzyme Q10 on neurological diseases: A review article

S Bagheri, R Haddadi, S Saki… - Frontiers in …, 2023 - frontiersin.org
Neurological disorders affect the nervous system. Biochemical, structural, or electrical
abnormalities in the spinal cord, brain, or other nerves lead to different symptoms, including …

Preclinical animal studies in ischemic stroke: Challenges and some solutions

SK Narayan, S Grace Cherian… - Animal Models and …, 2021 - Wiley Online Library
Despite the impressive efficacies demonstrated in preclinical research, hundreds of
potentially neuroprotective drugs have failed to provide effective neuroprotection for …

Combination of thrombolysis and statins in acute stroke is safe: results of the STARS randomized trial (stroke treatment with acute reperfusion and simvastatin)

J Montaner, A Bustamante, S García-Matas… - Stroke, 2016 - Am Heart Assoc
Background and Purpose—The STARS trial (Stroke Treatment With Acute Reperfusion and
Simvastatin) was conducted to demonstrate the efficacy and safety of simvastatin treatment …