Plasma phospho-tau in Alzheimer's disease: towards diagnostic and therapeutic trial applications

F Gonzalez-Ortiz, PR Kac, WS Brum… - Molecular …, 2023 - Springer
As the leading cause of dementia, Alzheimer's disease (AD) is a major burden on affected
individuals, their families and caregivers, and healthcare systems. Although AD can be …

Dementia with Lewy bodies: Impact of co‐pathologies and implications for clinical trial design

JB Toledo, C Abdelnour, RS Weil… - Alzheimer's & …, 2023 - Wiley Online Library
Dementia with Lewy bodies (DLB) is clinically defined by the presence of visual
hallucinations, fluctuations, rapid eye movement (REM) sleep behavioral disorder, and …

Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias

S Baiardi, C Quadalti, A Mammana, S Dellavalle… - Alzheimer's research & …, 2022 - Springer
Background Increasing evidence supports the use of plasma biomarkers of
neurodegeneration and neuroinflammation to screen and diagnose patients with dementia …

Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson's disease

L Batzu, S Rota, A Hye, A Heslegrave, D Trivedi… - npj Parkinson's …, 2022 - nature.com
Early identification of cognitive impairment in Parkinson's disease (PD) has important clinical
and research implications. The aim of our study was to investigate the role of plasma tau …

Diagnostic value of serum versus plasma phospho-tau for Alzheimer's disease

PR Kac, F Gonzalez-Ortiz, J Simrén, N Dewit… - Alzheimer's Research & …, 2022 - Springer
Background Blood phosphorylated tau (p-tau) forms are promising Alzheimer's disease (AD)
biomarkers, but validation in matrices other than ethylenediaminetetraacetic acid (EDTA) …

Medical comorbidities and ethnicity impact plasma Alzheimer's disease biomarkers: important considerations for clinical trials and practice

SE O'Bryant, M Petersen, J Hall… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Despite the clinical implementation, there remain significant gaps in our
knowledge regarding the impact of race/ethnicity or common medical comorbidity on plasma …

[HTML][HTML] Fluid and biopsy based biomarkers in Parkinson's disease

DG Coughlin, DJ Irwin - Neurotherapeutics, 2023 - Elsevier
Several advances in fluid and tissue-based biomarkers for use in Parkinson's disease (PD)
and other synucleinopathies have been made in the last several years. While work …

Clinical and diagnostic implications of Alzheimer's disease copathology in Lewy body disease

L Barba, S Abu-Rumeileh, H Barthel, F Massa… - Brain, 2024 - academic.oup.com
Concomitant Alzheimer's disease (AD) pathology is a frequent event in the context of Lewy
body disease (LBD), occurring in approximately half of all cases. Evidence shows that LBD …

Plasma NfL, GFAP, amyloid, and p-tau species as Prognostic biomarkers in Parkinson's disease

A Pilotto, NJ Ashton, A Lupini, B Battaglio, C Zatti… - Journal of …, 2024 - Springer
Introduction The prognostic role of plasma neurofilament light chain (NfL), phospho-tau, beta-
amyloid, and GFAP is still debated in Parkinson's disease (PD). Methods Plasma p-tau181 …

Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers

LL Gibson, C Abdelnour, J Chong… - Current Opinion in …, 2023 - journals.lww.com
Clinical trials in dementia with Lewy bodies: the evolving c... : Current Opinion in Neurology
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient …