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Plasma phospho-tau in Alzheimer's disease: towards diagnostic and therapeutic trial applications
As the leading cause of dementia, Alzheimer's disease (AD) is a major burden on affected
individuals, their families and caregivers, and healthcare systems. Although AD can be …
individuals, their families and caregivers, and healthcare systems. Although AD can be …
Dementia with Lewy bodies: Impact of co‐pathologies and implications for clinical trial design
Dementia with Lewy bodies (DLB) is clinically defined by the presence of visual
hallucinations, fluctuations, rapid eye movement (REM) sleep behavioral disorder, and …
hallucinations, fluctuations, rapid eye movement (REM) sleep behavioral disorder, and …
Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias
Background Increasing evidence supports the use of plasma biomarkers of
neurodegeneration and neuroinflammation to screen and diagnose patients with dementia …
neurodegeneration and neuroinflammation to screen and diagnose patients with dementia …
Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson's disease
Early identification of cognitive impairment in Parkinson's disease (PD) has important clinical
and research implications. The aim of our study was to investigate the role of plasma tau …
and research implications. The aim of our study was to investigate the role of plasma tau …
Diagnostic value of serum versus plasma phospho-tau for Alzheimer's disease
Background Blood phosphorylated tau (p-tau) forms are promising Alzheimer's disease (AD)
biomarkers, but validation in matrices other than ethylenediaminetetraacetic acid (EDTA) …
biomarkers, but validation in matrices other than ethylenediaminetetraacetic acid (EDTA) …
Medical comorbidities and ethnicity impact plasma Alzheimer's disease biomarkers: important considerations for clinical trials and practice
SE O'Bryant, M Petersen, J Hall… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Despite the clinical implementation, there remain significant gaps in our
knowledge regarding the impact of race/ethnicity or common medical comorbidity on plasma …
knowledge regarding the impact of race/ethnicity or common medical comorbidity on plasma …
[HTML][HTML] Fluid and biopsy based biomarkers in Parkinson's disease
Several advances in fluid and tissue-based biomarkers for use in Parkinson's disease (PD)
and other synucleinopathies have been made in the last several years. While work …
and other synucleinopathies have been made in the last several years. While work …
Clinical and diagnostic implications of Alzheimer's disease copathology in Lewy body disease
Concomitant Alzheimer's disease (AD) pathology is a frequent event in the context of Lewy
body disease (LBD), occurring in approximately half of all cases. Evidence shows that LBD …
body disease (LBD), occurring in approximately half of all cases. Evidence shows that LBD …
Plasma NfL, GFAP, amyloid, and p-tau species as Prognostic biomarkers in Parkinson's disease
Introduction The prognostic role of plasma neurofilament light chain (NfL), phospho-tau, beta-
amyloid, and GFAP is still debated in Parkinson's disease (PD). Methods Plasma p-tau181 …
amyloid, and GFAP is still debated in Parkinson's disease (PD). Methods Plasma p-tau181 …
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers
Clinical trials in dementia with Lewy bodies: the evolving c... : Current Opinion in Neurology
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient …
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient …