All known organisms encode 20 canonical amino acids by base triplets in the genetic code.
The cellular translational machinery produces proteins consisting mainly of these amino …

Malaria is a devastating parasitic disease affecting half of the world's population. The rapid
emergence of resistance against new antimalarial drugs, including artemisinin‐based …

The exploration of protease substrate specificity is generally restricted to naturally occurring
amino acids, limiting the degree of conformational space that can be surveyed. We …

M1 aminopeptidase is a metallopeptidase that plays a vital role in protein catabolism and
has been identified as a validated drug target in various parasites; however, our …

Proteases are enzymes that hydrolyze the peptide bond of peptide substrates and proteins.
Despite significant progress in recent years, one of the greatest challenges in the design …

Plasmodium parasites, the causative agents of malaria, have developed resistance to most
of our current antimalarial therapies, including artemisinin combination therapies which are …

Drug development for neglected diseases has been historically hampered due to lack of
market incentives. The advent of public domain resources containing chemical information …

The malaria parasite Plasmodium falciparum employs two metallo-aminopeptidases, Pf A-
M1 and Pf A-M17, which are essential for parasite survival. Compounds that inhibit the …

Plasmodium falciparum, the causative agent of malaria, remains a global health threat as
parasites continue to develop resistance to antimalarial drugs used throughout the world …

The Plasmodium falciparum M1 alanyl aminopeptidase and M17 leucyl aminopeptidase, Pf
M1AAP and Pf M17LAP, are potential targets for novel anti-malarial drug development …