Synthesis and molecular docking study of α-aminophosphonates as potential multi-targeting antibacterial agents
Antibacterial compounds that reduce extracellular polymeric substances (EPS) are needed
to avoid bacterial biofilms in water pipelines. Herein, green one-pot synthesis of α …
to avoid bacterial biofilms in water pipelines. Herein, green one-pot synthesis of α …
In silico screening and anticancer-apoptotic evaluation of newly synthesized thienopyrimidine/sulfonamide hybrids
EI Elmongy, FA Binjubair, OY Alshehri… - International Journal of …, 2023 - mdpi.com
This work describes the design and synthesis of new hybrids of thienopyrimidine and
sulfonamides. The binding affinity of the prepared compounds to FGFR-1 enzyme and …
sulfonamides. The binding affinity of the prepared compounds to FGFR-1 enzyme and …
Advances in structural identification of some thieno [2, 3-d] pyrimidine scaffolds as antitumor molecules: Synthetic approaches and control programmed cancer cell …
Abstract Thieno [2, 3-d] pyrimidine fragment is not only bioistostere to quinazoline ring but
also to purines which exist in nucleic acids responsible for several key biological processes …
also to purines which exist in nucleic acids responsible for several key biological processes …
Impact of Synthesized Indoloquinoline Analog to Isolates from Cryptolepis sanguinolenta on Tumor Growth Inhibition and Hepatotoxicity in Ehrlich Solid Tumor …
The study evaluated the antitumor efficacy of APAN,“synthesized indoloquinoline analog
derived from the parent neocryptolepine isolated from the roots of Cryptolepis …
derived from the parent neocryptolepine isolated from the roots of Cryptolepis …
Cytotoxic Potential of Novel Quinoline Derivative: 11-(1, 4-Bisaminopropylpiperazinyl) 5-methyl-5H-indolo [2, 3-b] quinoline against Different Cancer Cell Lines via …
SF Abd Elrahman, AAS Ahmed, D Abd Elsatar… - International Journal of …, 2023 - mdpi.com
The current study evaluated the cytotoxic activity of 11-(1, 4-bisaminopropylpiperazinyl) 5-
methyl-5H-indolo [2, 3-b] quinoline (BAPPN), a novel derivative of 5-methyl-5H-indolo [2, 3 …
methyl-5H-indolo [2, 3-b] quinoline (BAPPN), a novel derivative of 5-methyl-5H-indolo [2, 3 …
Antimicrobial Evaluation of Sulfonamides after Coupling with Thienopyrimidine Coplanar Structure
EI Elmongy, WS Alanazi, AI Aldawsari, AA Alfaouri… - Pharmaceuticals, 2024 - mdpi.com
This work describes the design and synthesis of three series of hybrids of thienopyrimidines
and sulfonamides. Dihydrofolate reductase enzyme was selected as a target for the in-silico …
and sulfonamides. Dihydrofolate reductase enzyme was selected as a target for the in-silico …
Pyrimidine: A Privileged Scaffold for the Development of Anticancer Agents as Protein Kinase Inhibitors (Recent Update)
MM Zeid, OM El-Badry, S Elmeligie… - Current …, 2025 - benthamdirect.com
The pyrimidine nucleus is a fundamental component of human DNA and RNA, as well as the
backbone of many therapeutic agents. Its significance in medicinal chemistry is well …
backbone of many therapeutic agents. Its significance in medicinal chemistry is well …
Molluscicidal and Larvicidal Potency of N-Heterocylic Analogs against Biomophalaria alexandrina Snails and Schistosoma mansoni Larval Stages
This work describes the synthesis of quinoline-based N--heterocyclic arenes and their
biological evaluation as molluscicides against adult Biomophalaria alexandrina snails as …
biological evaluation as molluscicides against adult Biomophalaria alexandrina snails as …
α-Amylase and α-Glucosidase Enzyme Inhibition, Molecular Docking, and Pharmacokinetic Studies of Natural Products from Dilenia indica L. Barks
The present study describes the isolation and structural elucidation of bioactive natural
products from the hydro ethanol extract of Dilenia indica L. barks (DIHEEB) and their …
products from the hydro ethanol extract of Dilenia indica L. barks (DIHEEB) and their …