Stabilization challenges and aggregation in protein-based therapeutics in the pharmaceutical industry

M Rahban, F Ahmad, MA Piatyszek, T Haertlé, L Saso… - RSC …, 2023 - pubs.rsc.org
Protein-based therapeutics have revolutionized the pharmaceutical industry and become
vital components in the development of future therapeutics. They offer several advantages …

Therapeutic proteins: developments, progress, challenges, and future perspectives

V Kumar, A Barwal, N Sharma, DS Mir, P Kumar… - 3 Biotech, 2024 - Springer
Proteins are considered magic molecules due to their enormous applications in the health
sector. Over the past few decades, therapeutic proteins have emerged as a promising …

Beyond In Vivo, Pharmaceutical Molecule Production in Cell-Free Systems and the Use of Noncanonical Amino Acids Therein

MG Casteleijn, U Abendroth, A Zemella… - Chemical …, 2025 - ACS Publications
Throughout history, we have looked to nature to discover and copy pharmaceutical solutions
to prevent and heal diseases. Due to the advances in metabolic engineering and the …

[HTML][HTML] Revolutionizing molecular design for innovative therapeutic applications through artificial intelligence

A Son, J Park, W Kim, Y Yoon, S Lee, Y Park, H Kim - Molecules, 2024 - mdpi.com
The field of computational protein engineering has been transformed by recent
advancements in machine learning, artificial intelligence, and molecular modeling, enabling …

[HTML][HTML] Integrating computational design and experimental approaches for next-generation biologics

A Son, J Park, W Kim, W Lee, Y Yoon, J Ji… - Biomolecules, 2024 - pmc.ncbi.nlm.nih.gov
Therapeutic protein engineering has revolutionized medicine by enabling the development
of highly specific and potent treatments for a wide range of diseases. This review examines …

Platelet-type von Willebrand disease: complex pathophysiology and insights on novel therapeutic and diagnostic strategies

A Fu, TDD Kazmirchuk, C Bradbury-Jost… - … in Thrombosis and …, 2024 - thieme-connect.com
von Willebrand disease (VWD) is the most common well-studied genetic bleeding disorder
worldwide. Much less is known about platelet-type VWD (PT-VWD), a rare platelet function …

Revolutionizing synthetic antibody design: Harnessing artificial intelligence and deep sequencing big data for unprecedented advances

E Gallo - Molecular Biotechnology, 2025 - Springer
Synthetic antibodies (Abs) represent a category of engineered proteins meticulously crafted
to replicate the functions of their natural counterparts. Such Abs are generated in vitro …

Suborgan Level Quantitation of Proteins in Tissues Delivered by Polymeric Nanocarriers

DK Agrohia, R Goswami, T Jantarat, YA Çiçek… - ACS …, 2024 - ACS Publications
Amidst the rapid growth of protein therapeutics as a drug class, there is an increased focus
on designing systems to effectively deliver proteins to target organs. Quantitative monitoring …

Non-hemolytic peptide classification using a quantum support vector machine

S Zhuang, J Tanner, Y Wu, D Huynh, W Liu… - Quantum Information …, 2024 - Springer
Quantum machine learning (QML) is one of the most promising applications of quantum
computation. Despite the theoretical advantages, it is still unclear exactly what kind of …

[HTML][HTML] Modulating the complement system through epitope-specific inhibition by complement C3 inhibitors

Z Chen, M Wang, W Duan, Y **a, H Liu… - Journal of Biological …, 2025 - Elsevier
As an integral part of the innate immune system, the complement system is a tightly
regulated proteolytic cascade, playing a critical role in microbial defense, inflammation …