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Stabilization challenges and aggregation in protein-based therapeutics in the pharmaceutical industry
Protein-based therapeutics have revolutionized the pharmaceutical industry and become
vital components in the development of future therapeutics. They offer several advantages …
vital components in the development of future therapeutics. They offer several advantages …
Therapeutic proteins: developments, progress, challenges, and future perspectives
V Kumar, A Barwal, N Sharma, DS Mir, P Kumar… - 3 Biotech, 2024 - Springer
Proteins are considered magic molecules due to their enormous applications in the health
sector. Over the past few decades, therapeutic proteins have emerged as a promising …
sector. Over the past few decades, therapeutic proteins have emerged as a promising …
Beyond In Vivo, Pharmaceutical Molecule Production in Cell-Free Systems and the Use of Noncanonical Amino Acids Therein
Throughout history, we have looked to nature to discover and copy pharmaceutical solutions
to prevent and heal diseases. Due to the advances in metabolic engineering and the …
to prevent and heal diseases. Due to the advances in metabolic engineering and the …
[HTML][HTML] Revolutionizing molecular design for innovative therapeutic applications through artificial intelligence
A Son, J Park, W Kim, Y Yoon, S Lee, Y Park, H Kim - Molecules, 2024 - mdpi.com
The field of computational protein engineering has been transformed by recent
advancements in machine learning, artificial intelligence, and molecular modeling, enabling …
advancements in machine learning, artificial intelligence, and molecular modeling, enabling …
[HTML][HTML] Integrating computational design and experimental approaches for next-generation biologics
A Son, J Park, W Kim, W Lee, Y Yoon, J Ji… - Biomolecules, 2024 - pmc.ncbi.nlm.nih.gov
Therapeutic protein engineering has revolutionized medicine by enabling the development
of highly specific and potent treatments for a wide range of diseases. This review examines …
of highly specific and potent treatments for a wide range of diseases. This review examines …
Platelet-type von Willebrand disease: complex pathophysiology and insights on novel therapeutic and diagnostic strategies
von Willebrand disease (VWD) is the most common well-studied genetic bleeding disorder
worldwide. Much less is known about platelet-type VWD (PT-VWD), a rare platelet function …
worldwide. Much less is known about platelet-type VWD (PT-VWD), a rare platelet function …
Revolutionizing synthetic antibody design: Harnessing artificial intelligence and deep sequencing big data for unprecedented advances
E Gallo - Molecular Biotechnology, 2025 - Springer
Synthetic antibodies (Abs) represent a category of engineered proteins meticulously crafted
to replicate the functions of their natural counterparts. Such Abs are generated in vitro …
to replicate the functions of their natural counterparts. Such Abs are generated in vitro …
Suborgan Level Quantitation of Proteins in Tissues Delivered by Polymeric Nanocarriers
Amidst the rapid growth of protein therapeutics as a drug class, there is an increased focus
on designing systems to effectively deliver proteins to target organs. Quantitative monitoring …
on designing systems to effectively deliver proteins to target organs. Quantitative monitoring …
Non-hemolytic peptide classification using a quantum support vector machine
Quantum machine learning (QML) is one of the most promising applications of quantum
computation. Despite the theoretical advantages, it is still unclear exactly what kind of …
computation. Despite the theoretical advantages, it is still unclear exactly what kind of …
[HTML][HTML] Modulating the complement system through epitope-specific inhibition by complement C3 inhibitors
Z Chen, M Wang, W Duan, Y **a, H Liu… - Journal of Biological …, 2025 - Elsevier
As an integral part of the innate immune system, the complement system is a tightly
regulated proteolytic cascade, playing a critical role in microbial defense, inflammation …
regulated proteolytic cascade, playing a critical role in microbial defense, inflammation …