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Perivascular innervation: a multiplicity of roles in vasomotor control and myoendothelial signaling
The control of vascular resistance and tissue perfusion reflect coordinated changes in the
diameter of feed arteries and the arteriolar networks they supply. Against a background of …
diameter of feed arteries and the arteriolar networks they supply. Against a background of …
Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation
Numerous mediators and drugs regulate blood flow or arterial pressure by acting on
vascular tone, involving cyclic nucleotide intracellular pathways. These signals lead to …
vascular tone, involving cyclic nucleotide intracellular pathways. These signals lead to …
Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor–mediated relaxation of renal arteries in hypertension
KCNQ4-encoded voltage-dependent potassium (Kv7. 4) channels are important regulators
of vascular tone that are severely compromised in models of hypertension. However, there is …
of vascular tone that are severely compromised in models of hypertension. However, there is …
The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure
The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its
role is not completely understood. In this study, we tested the hypothesis that the CaSR …
role is not completely understood. In this study, we tested the hypothesis that the CaSR …
Contribution of Kv7. 4/Kv7. 5 heteromers to intrinsic and calcitonin gene-related peptide–induced cerebral reactivity
Objective—Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity
and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP) …
and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP) …
Different β‐adrenoceptor subtypes coupling to cAMP or NO/cGMP pathways: implications in the relaxant response of rat conductance and resistance vessels
Background and Purpose To analyse the relative contribution of β1‐, β2‐and β3‐
adrenoceptors (Adrb) to vasodilatation in conductance and resistance vessels, assessing …
adrenoceptors (Adrb) to vasodilatation in conductance and resistance vessels, assessing …
Kv7 channel activation underpins EPAC-dependent relaxations of rat arteries
Objective—To establish the role of Kv7 channels in EPAC (exchange protein directly
activated by cAMP)-dependent relaxations of the rat vasculature and to investigate whether …
activated by cAMP)-dependent relaxations of the rat vasculature and to investigate whether …
β3‐Adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell‐derived NO and vascular relaxation in small arteries
Background and Purpose In response to noradrenaline, healthy perivascular adipose tissue
(PVAT) exerts an anticontractile effect on adjacent small arterial tissue. Organ bath solution …
(PVAT) exerts an anticontractile effect on adjacent small arterial tissue. Organ bath solution …
TRPM 4 inhibitor 9‐phenanthrol activates endothelial cell intermediate conductance calcium‐activated potassium channels in rat isolated mesenteric artery
Background and Purpose Smooth muscle transient receptor potential melastatin 4 (TRPM 4)
channels play a fundamental role in the development of the myogenic arterial constriction …
channels play a fundamental role in the development of the myogenic arterial constriction …
Dynein coordinates β2-adrenoceptor-mediated relaxation in normotensive and hypertensive rat mesenteric arteries
Background: The voltage-gated potassium channel (Kv) 7.4 and Kv7. 5 channels contribute
to the β-adrenoceptor-mediated vasodilatation. In arteries from hypertensive rodents, the …
to the β-adrenoceptor-mediated vasodilatation. In arteries from hypertensive rodents, the …