The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome

SL Miller, PS Huppi, C Mallard - The Journal of physiology, 2016 - Wiley Online Library
Fetal growth restriction (FGR) is a significant complication of pregnancy describing a fetus
that does not grow to full potential due to pathological compromise. FGR affects 3–9% of …

Network models to enhance the translational impact of cross-species studies

JK Brynildsen, K Rajan, MX Henderson… - Nature Reviews …, 2023 - nature.com
Neuroscience studies are often carried out in animal models for the purpose of
understanding specific aspects of the human condition. However, the translation of findings …

[HTML][HTML] Prenatal exposure to air pollution is associated with structural changes in the neonatal brain

B Bos, B Barratt, D Batalle, O Gale-Grant… - Environment …, 2023 - Elsevier
Background Prenatal exposure to air pollution is associated with adverse neurologic
consequences in childhood. However, the relationship between in utero exposure to air …

Early brain connectivity alterations and cognitive impairment in a rat model of Alzheimer's disease

E Muñoz-Moreno, R Tudela, X López-Gil… - Alzheimer's research & …, 2018 - Springer
Abstract Background Animal models of Alzheimer's disease (AD) are essential to
understanding the disease progression and to development of early biomarkers. Because …

Models of Intrauterine growth restriction and fetal programming in rabbits

J Lopez‐Tello, M Arias‐Alvarez… - Molecular …, 2019 - Wiley Online Library
Intrauterine growth restriction (IUGR) affects approximately 10% of human pregnancies
globally and has immediate and life‐long consequences for offspring health. However, the …

Detection and assessment of brain injury in the growth-restricted fetus and neonate

A Malhotra, M Ditchfield, MC Fahey… - Pediatric …, 2017 - nature.com
Fetal growth restriction (FGR) is a common complication of pregnancy and, in severe cases,
is associated with elevated rates of perinatal mortality, neonatal morbidity, and poor …

M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's disease

S Fernández-García, S Conde-Berriozabal… - Elife, 2020 - elifesciences.org
Huntington's disease (HD) is a neurological disorder characterized by motor disturbances.
HD pathology is most prominent in the striatum, the central hub of the basal ganglia. The …

Thyroid hormone analogues: Promising therapeutic avenues to improve the neurodevelopmental outcomes of intrauterine growth restriction

G Chincarini, DW Walker, F Wong… - Journal of …, 2024 - Wiley Online Library
Intrauterine growth restriction (IUGR) is a pregnancy complication impairing fetal growth and
development. The compromised development is often attributed to disruptions of oxygen …

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity

AG Yates, E Kislitsyna, C Alfonso Martin… - Journal of …, 2022 - Springer
Encephalopathy of prematurity (EoP) affects approximately 30% of infants born< 32 weeks
gestation and is highly associated with inflammation in the foetus. Here we evaluated the …

Programming the brain: Common outcomes and gaps in knowledge from animal studies of IUGR

DS Hunter, SJ Hazel, KL Kind, JA Owens… - Physiology & …, 2016 - Elsevier
IUGR in humans is associated with impaired pre-and postnatal neurodevelopment, and
subsequent postnatal cognition, resulting in lower IQ, poorer memory, visuomotor and …