Mass spectrometry-based techniques to elucidate the sugar code

M Grabarics, M Lettow, C Kirschbaum, K Greis… - Chemical …, 2021 - ACS Publications
Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

Gas-phase infrared spectroscopy of glycans and glycoconjugates

K Greis, C Kirschbaum, G von Helden… - Current Opinion in …, 2022 - Elsevier
Glycans are intrinsically complex biomolecules that pose particular analytical challenges.
Standard workflows for glycan analysis are based on mass spectrometry, often coupled with …

Toward high-throughput cryogenic IR fingerprinting of mobility-separated glycan isomers

S Warnke, A Ben Faleh, TR Rizzo - ACS measurement science …, 2021 - ACS Publications
Infrared (IR) spectroscopy is a powerful tool used to infer detailed structural information on
molecules, often in conjunction with quantum-chemical calculations. When applied to …

Predicting structural motifs of glycosaminoglycans using cryogenic infrared spectroscopy and random forest

J Riedel, M Lettow, M Grabarics… - Journal of the …, 2023 - ACS Publications
In recent years, glycosaminoglycans (GAGs) have emerged into the focus of biochemical
and biomedical research due to their importance in a variety of physiological processes …

High-throughput multiplexed infrared spectroscopy of ion mobility-separated species using Hadamard transform

V Yatsyna, AH Abikhodr, A Ben Faleh… - Analytical …, 2022 - ACS Publications
Coupling vibrational ion spectroscopy with high-resolution ion mobility separation offers a
promising approach for detailed analysis of biomolecules in the gas phase. Improvements in …

Introducing ion mobility mass spectrometry in brain glycosaminoglycomics: application to chondroitin/dermatan sulfate octasaccharide domains

M Sarbu, DG Seidler, DE Clemmer… - Journal of the American …, 2024 - ACS Publications
Glycosaminoglycans (GAGs) are sulfated linear O-glycan chains abundantly expressed in
the extracellular matrix (ECM). Among GAGs, chondroitin sulfate (CS) and dermatan sulfate …

Glycomics by ion mobility tandem mass spectrometry of chondroitin sulfate disaccharide domain in biglycan

M Sarbu, R Ica, E Sharon, DE Clemmer… - Journal of Mass …, 2023 - Wiley Online Library
Biglycan (BGN), a small leucine‐rich repeat proteoglycan, is involved in a variety of
pathological processes including malignant transformation, for which the upregulation of …

Cold-ion Spectroscopy of Carbohydrates

K PAGEL - Glycoprotein Analysis, 2024 - books.google.com
Carbohydrates are ubiquitous in nature. 1, 2 Besides their function as energy storage,
glycans and glycoconjugates involving peptides (glycopeptides), proteins (glycoproteins) …

Cold-ion Spectroscopy of Carbohydrates

M Safferthal, Ł Polewski, CW Chang, K Greis, K Pagel - 2024 - books.rsc.org
Carbohydrates are ubiquitous in nature. 1, 2 Besides their function as energy storage,
glycans and glycoconjugates involving peptides (glycopeptides), proteins (glycoproteins) …

Methods and Materials for Studying Proteoglycans and Glycosaminoglycans

R Karlsson, MN Grønset, C Chuang, JA Hippensteel… - 2024 - books.rsc.org
Cellular processes in multi-cellular organisms depend on the interaction of biological
molecules, which is driven by specific molecular recognition. Glycoproteins present on the …