Much progress has been made toward deciphering RHO GTPase functions, and many
studies have convincingly demonstrated that altered signal transduction through RHO …

Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Lung cancer is one of the deadliest cancers in the world. Two of the most common subtypes,
lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), have drastically …

Cell migration is dependent on the dynamic formation and disassembly of actin filament–
based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as …

Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …

Understanding the organizational logic of neural circuits requires deciphering the biological
basis of neuronal diversity and identity, but there is no consensus on how neuron types …

Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are clinically
disparate primary liver cancers with etiological and biological heterogeneity. We identified …

Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and
are implicated in epithelial to mesenchymal transition, cell-cycle progression …

All cells sense and respond to various mechanical forces in and mechanical properties of
their environment. To respond appropriately, cells must be able to sense the location …

Neutrophils are part of a family of granulocytes that, together with eosinophils and basophils,
play an essential role in innate immunity. Neutrophils are the most abundant circulating …