Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
Small GTP-binding proteins
Y Takai, T Sasaki, T Matozaki - Physiological reviews, 2001 - journals.physiology.org
Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …
constitute a superfamily consisting of more than 100 members. This superfamily is …
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
W Kolch - Biochemical Journal, 2000 - portlandpress.com
The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-
regulated kinase) pathway is at the heart of signalling networks that govern proliferation …
regulated kinase) pathway is at the heart of signalling networks that govern proliferation …
Signal transduction through MAP kinase cascades
TS Lewis, PS Shapiro, NG Ahn - Advances in cancer research, 1998 - Elsevier
Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …
Oxidative stress and gene regulation
RG Allen, M Tresini - Free Radical Biology and Medicine, 2000 - Elsevier
Reactive oxygen species are produced by all aerobic cells and are widely believed to play a
pivotal role in aging as well as a number of degenerative diseases. The consequences of …
pivotal role in aging as well as a number of degenerative diseases. The consequences of …
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
The first step of RAF activation involves binding to active RAS, resulting in the recruitment of
RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction …
RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction …
Increasing complexity of Ras signaling
The initial discovery that ras genes endowed retroviruses with potent carcinogenic
properties and the subsequent determination that mutated ras genes were present in a wide …
properties and the subsequent determination that mutated ras genes were present in a wide …
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
LM Luttrell, FL Roudabush, EW Choy… - Proceedings of the …, 2001 - National Acad Sciences
Using both confocal immunofluorescence microscopy and biochemical approaches, we
have examined the role of β-arrestins in the activation and targeting of extracellular signal …
have examined the role of β-arrestins in the activation and targeting of extracellular signal …
The complexity of Raf-1 regulation
DK Morrison, RE Cutler Jr - Current opinion in cell biology, 1997 - Elsevier
The activation of the serine/threonine kinase Raf-1 is proving to be an intricate multistep
process. Recent advances in elucidating how Raf-1 becomes activated in response to …
process. Recent advances in elucidating how Raf-1 becomes activated in response to …
Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
R Khosravi-Far, PA Solski, GJ Clark… - … and cellular biology, 1995 - Am Soc Microbiol
Although substantial evidence supports a critical role for the activation of Raf-1 and mitogen-
activated protein kinases (MAPKs) in oncogenic Ras-mediated transformation, recent …
activated protein kinases (MAPKs) in oncogenic Ras-mediated transformation, recent …