Asthma is one of the most common chronic immunological diseases in humans, affecting
people from childhood to old age. Progress in treating asthma has been relatively slow and …

Inflammation, structural, and functional abnormalities within the airways are key features of
asthma. Although these processes are well documented, their expression varies across the …

Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct
molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n= 51) …

Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and
likely includes a subgroup that is biologically comparable to asthma. Studying asthma …

Background Compositional differences in the bronchial bacterial microbiota have been
associated with asthma, but it remains unclear whether the findings are attributable to …

Asthma is a disease of reversible airflow obstruction characterised clinically by wheezing,
shortness of breath, and coughing. Increases in airway type 2 cytokine activity, including …

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing
millions of global deaths each year. To alleviate this burden, improved prognostication and …

Asthma is a chronic inflammatory airway disease characterized by variable airflow
obstruction in response to a wide range of exogenous stimuli. The airway epithelium is the …

Background Bronchial airway expression profiling has identified inflammatory
subphenotypes of asthma, but the invasiveness of this technique has limited its application …

Rationale: Activation of type 2 cytokine pathways plays a central role in a large subset of
subjects with asthma. Th2-high and Th2-low asthma have distinct clinical, pathologic, and …