Identification of 1, 3, 4-oxadiazoles as tubulin-targeted anticancer agents: a combined field-based 3D-QSAR, pharmacophore model-based virtual screening …
Cancer is one of the most prominent causes of death worldwide and tubulin is a crucial
protein of cytoskeleton that maintains essential cellular functions including cell division as …
protein of cytoskeleton that maintains essential cellular functions including cell division as …
Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors
N Scarano, E Abbotto, F Musumeci, A Salis… - International Journal of …, 2023 - mdpi.com
Sirtuin isoform 2 (SIRT2) is one of the seven sirtuin isoforms present in humans, being
classified as class III histone deacetylases (HDACs). Based on the high sequence similarity …
classified as class III histone deacetylases (HDACs). Based on the high sequence similarity …
Chemical Composition, In vitro and In silico Evaluation of Essential Oil Extracted from Mentha Piperita L. for Lung Cancer
B Singh, A Kumar, KS Prajapati, S Patel… - Letters in Drug …, 2024 - benthamdirect.com
Background Mentha piperita, a naturally occurring herb, is utilized in medicinal formulations.
It possesses abundant bioactive elements, including flavonoids and phenolic acid …
It possesses abundant bioactive elements, including flavonoids and phenolic acid …
Design, synthesis, in silico and biological evaluation of new indole based oxadiazole derivatives targeting estrogen receptor alpha
A series of new indole-oxadiazole derivatives was designed and synthesized to develop
potential anti-breast cancer agents. The compounds exhibited significant inhibitory activity …
potential anti-breast cancer agents. The compounds exhibited significant inhibitory activity …
Multilayered screening for multi-targeted anti-Alzheimer's and anti-Parkinson's agents through structure-based pharmacophore modelling, MCDM, docking, molecular …
N Chhabra, BW Matore, N Lakra, P Banjare… - In Silico …, 2025 - Springer
Alzheimer's disease (AD) and Parkinson's disease (PD) are neurological conditions that
primarily impact the elderly having distinctive traits and some similarities in terms of …
primarily impact the elderly having distinctive traits and some similarities in terms of …
[HTML][HTML] Identification of coumarin derivatives targeting acetylcholinesterase for Alzheimer's disease by field-based 3D-QSAR, pharmacophore model-based virtual …
Alzheimer's disease (AD) leads to gradual memory loss including other compromised
cognitive abilities. Acetylcholinesterase (AChE), an important biochemical enzyme from the …
cognitive abilities. Acetylcholinesterase (AChE), an important biochemical enzyme from the …
In silico Screening of Plectranthus amboinicus and Hyptis suaveolens Phytochemicals: Novel Repellents Targeting Odorant Binding Proteins of Aedes aegypti and …
T Jebastin, JJ Wilson, N Sisubalan… - Anti-Infective …, 2025 - benthamdirect.com
Background and Aim Mosquitoes significantly threaten public health, transmitting dangerous
diseases to humans and animals. Conventional insecticide spraying, while common, has …
diseases to humans and animals. Conventional insecticide spraying, while common, has …