• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Aim This clinical practice guideline for the evaluation and diagnosis of chest pain provides
recommendations and algorithms for clinicians to assess and diagnose chest pain in adult …

Background The assessment of calibration performance of risk prediction models based on
regression or more flexible machine learning algorithms receives little attention. Main text …

Health professionals are encouraged to take the ESC Guidelines fully into account when
exercising their clinical judgment, as well as in the determination and the implementation of …

The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual
Prognosis Or Diagnosis) Statement includes a 22-item checklist, which aims to improve the …

Background: Stress cardiac magnetic resonance imaging (CMR) has demonstrated
excellent diagnostic and prognostic value in single-center studies. Objectives: This study …

Aims We hypothesized that the modified Diamond–Forrester (DF) prediction model
overestimates probability of coronary artery disease (CAD). The aim of this study was to …

Aims To provide a pooled estimation of contemporary pre-test probabilities (PTPs) of
significant coronary artery disease (CAD) across clinical patient categories, re-evaluate the …

Aims Symptom-based pretest probability scores that estimate the likelihood of obstructive
coronary artery disease (CAD) in stable chest pain have moderate accuracy. We sought to …

Importance Nearly 10 million US adults experience stable angina, which occurs when
myocardial oxygen supply does not meet demand, resulting in myocardial ischemia. Stable …