Abstract G-quadruplexes (G4s), higher-order DNA and RNA secondary structures featuring
guanine-rich nucleic acid sequences with various conformations, are widely distributed in …

G‐quadruplexes are secondary structures formed in G‐rich sequences in DNA and RNA.
Considerable research over the past three decades has led to in‐depth insight into these …

Cell identity is maintained by activation of cell-specific gene programs, regulated by
epigenetic marks, transcription factors and chromatin organization. DNA G-quadruplex (G4) …

G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of
genome. G-quadruplexes have been proved to be involved in the regulation of replication …

Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …

Alternative DNA conformations, termed non-B DNA structures, can affect transcription, but
the underlying mechanisms and their functional impact have not been systematically …

Chemical modifications of DNA and RNA regulate genome functions or trigger mutagenesis
resulting in aging or cancer. Oxidations of macromolecules, including DNA, are common …

Guanine-rich DNA strands can fold into non-canonical four-stranded secondary structures
named G-quadruplexes (G4). Experimental evidences suggest that G4-DNA surrounding …

G‐quadruplexes (G4) are four‐stranded structures formed from guanine‐rich
oligonucleotides. Their defined 3D structures and polymorphic nature set them apart from …

DNA sequences capable of forming G-quadruplex (G4) structures can be predicted and
mapped in plant genomes using computerized pattern search programs. Non-telomeric G4 …