Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

Macromolecular phase separation is being recognized for its potential importance and
relevance as a driver of spatial organization within cells. Here, we describe a framework …

Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of
distinct biomolecular condensates that form via phase separation coupled to percolation …

Liquid–liquid phase separation and related phase transitions have emerged as generic
mechanisms in living cells for the formation of membraneless compartments or biomolecular …

Coacervates are condensed liquid-like droplets formed by liquid–liquid phase separation of
molecules through multiple weak associative interactions. In recent years it has emerged …

Bottom-up assembly of higher-order cytomimetic systems capable of coordinated physical
behaviours, collective chemical signalling and spatially integrated processing is a key …

Coacervates are condensed liquid-like droplets, usually formed with oppositely charged
polymeric molecules. They have been studied extensively in colloid and interface science …

The concept of phase-separation-mediated formation of biomolecular condensates provides
a new framework to understand cellular organization and cooperativity-dependent cellular …

Liquid-liquid phase separation of multivalent proteins and RNAs drives the formation of
biomolecular condensates that facilitate membrane-free compartmentalization of subcellular …

A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …