Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …

Today, Fmoc SPPS is the method of choice for peptide synthesis. Very‐high‐quality Fmoc
building blocks are available at low cost because of the economies of scale arising from …

Post-translational modifications (PTMs) produce significant changes in the structural
properties of intrinsically disordered proteins (IDPs) by affecting their energy landscapes …

The presence of DNA in the cytoplasm is normally a sign of microbial infections and is
quickly detected by cyclic GMP-AMP synthase (cGAS) to elicit anti-infection immune …

Metabolism research is undergoing a renaissance because many diseases are increasingly
recognized as being characterized by perturbations in intracellular metabolic regulation …

Regulatory protein phosphorylation controls normal and pathophysiological signaling in
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …

Post-transcriptional modifications have critical roles in tRNA stability and function,,–. In
thermophiles, tRNAs are heavily modified to maintain their thermal stability under extreme …

Increasing evidence has shown that population dynamics are qualitatively different from
single-cell behaviors. Reporters to probe dynamic, single-cell behaviors are desirable yet …

Post translational modifications (PTMs) are involved in variety of cellular activities and
phosphorylation is one of the most extensively studied PTM, which regulates a number of …

Protein folding is a biophysical process by which proteins reach a specific three-dimensional
structure. The amino acid sequence of a polypeptide chain contains all the information …