Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

The substantial use of antibiotics in the clinic, combined with a dearth of new antibiotic
classes, has led to a gradual increase in the resistance of bacterial pathogens to these …

The most common prokaryotic signal transduction mechanisms are the one-component
systems in which a single polypeptide contains both a sensory domain and a DNA-binding …

Drug efflux pumps play a key role in drug resistance and also serve other functions in
bacteria. There has been a growing list of multidrug and drug-specific efflux pumps …

Antibiotic resistance continues to plague antimicrobial chemotherapy of infectious disease.
And while true biocide resistance is as yet unrealized, in vitro and in vivo episodes of …

We have developed a general profile for the proteins of the TetR family of repressors. The
stretch that best defines the profile of this family is made up of 47 amino acid residues that …

Antibiotic resistance continues to hamper antimicrobial chemotherapy of infectious disease,
and while biocide resistance outside of the laboratory is as yet unrealized, in vitro and in …

Aminoglycosides (35) are a vital component of antipseudomonal chemotherapy implicated
in the treatment of a variety of infections (9, 45), particularly pulmonary infections in cystic …

Antibiotic resistance of bacterial pathogens is a fast emerging global crisis and an
understanding of the underlying resistance mechanisms is paramount for design and …