Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms
An earlier diagnosis is a key strategy for improving the outcomes of patients with cancer.
However, achieving this goal can be challenging, particularly for the growing number of …
However, achieving this goal can be challenging, particularly for the growing number of …
Metabolomic biomarkers in blood samples identify cancers in a mixed population of patients with nonspecific symptoms
Purpose: Early diagnosis of cancer is critical for improving patient outcomes, but cancers
may be hard to diagnose if patients present with nonspecific signs and symptoms. We have …
may be hard to diagnose if patients present with nonspecific signs and symptoms. We have …
First results from five multidisciplinary diagnostic centre (MDC) projects for non-specific but concerning symptoms, possibly indicative of cancer
D Chapman, V Poirier, D Vulkan, K Fitzgerald… - British Journal of …, 2020 - nature.com
Background Patients with non-specific symptoms often experience longer times to diagnosis
and poorer clinical outcomes than those with site-specific symptoms. This paper reports …
and poorer clinical outcomes than those with site-specific symptoms. This paper reports …
Role of primary care physician factors on diagnostic testing and referral decisions for symptoms of possible cancer: a systematic review
Background Missed opportunities for diagnosing cancer cause patients harm and have
been attributed to suboptimal use of tests and referral pathways in primary care. Primary …
been attributed to suboptimal use of tests and referral pathways in primary care. Primary …
Consultations for clinical features of possible cancer and associated urgent referrals before and during the COVID-19 pandemic: an observational cohort study from …
Background It remains unclear to what extent reductions in urgent referrals for suspected
cancer during the COVID-19 pandemic were the result of fewer patients attending primary …
cancer during the COVID-19 pandemic were the result of fewer patients attending primary …
The association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentations
Background We aimed to understand the time period of cancer diagnosis and the cancer
types detected in primary care patients with unexpected weight loss (UWL) to inform cancer …
types detected in primary care patients with unexpected weight loss (UWL) to inform cancer …
Conceptual framework to guide early diagnosis programs for symptomatic cancer as part of global cancer control
Diagnosing cancer earlier can enable timely treatment and optimize outcomes. Worldwide,
national cancer control plans increasingly encompass early diagnosis programs for …
national cancer control plans increasingly encompass early diagnosis programs for …
The effectiveness of the Guy's Rapid Diagnostic Clinic (RDC) in detecting cancer and serious conditions in vague symptom patients
SO Dolly, G Jones, P Allchorne, D Wheeler, S Ali… - British journal of …, 2021 - nature.com
Abstract Background Rapid Diagnostic Clinics (RDC) are being expanded nationally by
NHS England. Guy's RDC established a pathway for GPs and internal referrals for patients …
NHS England. Guy's RDC established a pathway for GPs and internal referrals for patients …
Rapid cancer diagnosis for patients with vague symptoms: a cost-effectiveness study
B Sewell, M Jones, H Gray, H Wilkes… - British Journal of …, 2020 - bjgp.org
Background A pilot rapid diagnosis centre (RDC) allows GPs within targeted clusters to refer
adults with vague and/or non-specific symptoms suspicious of cancer, who do not meet …
adults with vague and/or non-specific symptoms suspicious of cancer, who do not meet …
Contrasting effects of comorbidities on emergency colon cancer diagnosis: a longitudinal data-linkage study in England
Background One in three colon cancers are diagnosed as an emergency, which is
associated with worse cancer outcomes. Chronic conditions (comorbidities) affect large …
associated with worse cancer outcomes. Chronic conditions (comorbidities) affect large …