Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms

C Renzi, A Kaushal, J Emery, W Hamilton… - Nature reviews clinical …, 2019 - nature.com
An earlier diagnosis is a key strategy for improving the outcomes of patients with cancer.
However, achieving this goal can be challenging, particularly for the growing number of …

Metabolomic biomarkers in blood samples identify cancers in a mixed population of patients with nonspecific symptoms

JR Larkin, S Anthony, VA Johanssen, T Yeo… - Clinical Cancer …, 2022 - AACR
Purpose: Early diagnosis of cancer is critical for improving patient outcomes, but cancers
may be hard to diagnose if patients present with nonspecific signs and symptoms. We have …

First results from five multidisciplinary diagnostic centre (MDC) projects for non-specific but concerning symptoms, possibly indicative of cancer

D Chapman, V Poirier, D Vulkan, K Fitzgerald… - British Journal of …, 2020 - nature.com
Background Patients with non-specific symptoms often experience longer times to diagnosis
and poorer clinical outcomes than those with site-specific symptoms. This paper reports …

Role of primary care physician factors on diagnostic testing and referral decisions for symptoms of possible cancer: a systematic review

V Hardy, A Yue, S Archer, SWD Merriel, M Thompson… - BMJ open, 2022 - bmjopen.bmj.com
Background Missed opportunities for diagnosing cancer cause patients harm and have
been attributed to suboptimal use of tests and referral pathways in primary care. Primary …

Consultations for clinical features of possible cancer and associated urgent referrals before and during the COVID-19 pandemic: an observational cohort study from …

BD Nicholson, JM Ordóñez-Mena, S Lay-Flurrie… - British journal of …, 2022 - nature.com
Background It remains unclear to what extent reductions in urgent referrals for suspected
cancer during the COVID-19 pandemic were the result of fewer patients attending primary …

The association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentations

BD Nicholson, W Hamilton, C Koshiaris, JL Oke… - British journal of …, 2020 - nature.com
Background We aimed to understand the time period of cancer diagnosis and the cancer
types detected in primary care patients with unexpected weight loss (UWL) to inform cancer …

Conceptual framework to guide early diagnosis programs for symptomatic cancer as part of global cancer control

MM Koo, K Unger-Saldaña, AD Mwaka… - JCO global …, 2021 - ascopubs.org
Diagnosing cancer earlier can enable timely treatment and optimize outcomes. Worldwide,
national cancer control plans increasingly encompass early diagnosis programs for …

The effectiveness of the Guy's Rapid Diagnostic Clinic (RDC) in detecting cancer and serious conditions in vague symptom patients

SO Dolly, G Jones, P Allchorne, D Wheeler, S Ali… - British journal of …, 2021 - nature.com
Abstract Background Rapid Diagnostic Clinics (RDC) are being expanded nationally by
NHS England. Guy's RDC established a pathway for GPs and internal referrals for patients …

Rapid cancer diagnosis for patients with vague symptoms: a cost-effectiveness study

B Sewell, M Jones, H Gray, H Wilkes… - British Journal of …, 2020 - bjgp.org
Background A pilot rapid diagnosis centre (RDC) allows GPs within targeted clusters to refer
adults with vague and/or non-specific symptoms suspicious of cancer, who do not meet …

Contrasting effects of comorbidities on emergency colon cancer diagnosis: a longitudinal data-linkage study in England

C Renzi, G Lyratzopoulos, W Hamilton… - BMC health services …, 2019 - Springer
Background One in three colon cancers are diagnosed as an emergency, which is
associated with worse cancer outcomes. Chronic conditions (comorbidities) affect large …