Cancer stem cells: advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G **ao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Revisiting the PD-1 pathway

N Patsoukis, Q Wang, L Strauss, VA Boussiotis - Science advances, 2020 - science.org
Programmed Death-1 (PD-1; CD279) is an inhibitory receptor induced in activated T cells.
PD-1 engagement by its ligands, PD-L1 and PD-L2, maintains peripheral tolerance but also …

Patient-derived xenograft (PDX) models, applications and challenges in cancer research

S Abdolahi, Z Ghazvinian, S Muhammadnejad… - Journal of Translational …, 2022 - Springer
The establishing of the first cancer models created a new perspective on the identification
and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft …

Oxidative stress, inflammation, and cancer: how are they linked?

S Reuter, SC Gupta, MM Chaturvedi… - Free radical biology and …, 2010 - Elsevier
Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment

LTH Phi, IN Sari, YG Yang, SH Lee, N Jun… - Stem cells …, 2018 - Wiley Online Library
Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …

A cellular hierarchy in melanoma uncouples growth and metastasis

P Karras, I Bordeu, J Pozniak, A Nowosad, C Pazzi… - Nature, 2022 - nature.com
Although melanoma is notorious for its high degree of heterogeneity and plasticity,, the
origin and magnitude of cell-state diversity remains poorly understood. Equally, it is unclear …

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

JE Visvader, GJ Lindeman - Nature reviews cancer, 2008 - nature.com
Solid tumours are an enormous cancer burden and a major therapeutic challenge. The
cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for …

The cancer stem cell: premises, promises and challenges

H Clevers - Nature medicine, 2011 - nature.com
Over the last decade, the notion that tumors are maintained by their own stem cells, the so-
called cancer stem cells, has created great excitement in the research community. This …

Identification of tumor antigens with immunopeptidomics

C Chong, G Coukos, M Bassani-Sternberg - Nature biotechnology, 2022 - nature.com
The identification of actionable tumor antigens is indispensable for the development of
several cancer immunotherapies, including T cell receptor–transduced T cells and patient …

ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

Y Hu, GK Smyth - Journal of immunological methods, 2009 - Elsevier
ELDA is a software application for limiting dilution analysis (LDA), with particular attention to
the needs of stem cell assays. It is the first limiting dilution analysis software to provide …