Co-targeting of MDM2 and CDK4/6 with siremadlin and ribociclib for the treatment of patients with well-differentiated or dedifferentiated liposarcoma: results from a …
AR Abdul Razak, S Bauer, C Suarez, CC Lin… - Clinical Cancer …, 2022 - AACR
Abstract Purpose: Well-differentiated (WDLPS) and dedifferentiated (DDLPS) liposarcoma
are characterized by co-amplification of the murine double minute-2 (MDM2) and cyclin …
are characterized by co-amplification of the murine double minute-2 (MDM2) and cyclin …
GDF15 promotes cell growth, migration, and invasion in gastric cancer by inducing STAT3 activation
M Joo, D Kim, MW Lee, HJ Lee, JM Kim - International Journal of …, 2023 - mdpi.com
Growth differentiation factor 15 (GDF15) has been reported to play an important role in
cancer and is secreted and involved in the progression of various cancers, including ovarian …
cancer and is secreted and involved in the progression of various cancers, including ovarian …
The GDF15-GFRAL axis mediates chemotherapy-induced fatigue in mice
B Chelette, CL Chidomere, R Dantzer - Brain, behavior, and immunity, 2023 - Elsevier
Cancer-related fatigue is defined as a distressing persistent subjective sense of physical,
emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment …
emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment …
Integrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors
KK Wong, NW Bateman, CW Ng, YTM Tsang… - Journal of translational …, 2022 - Springer
Background Low-grade serous ovarian cancer (LGSOC) is a rare disease that occurs more
frequently in younger women than those with high-grade disease. The current treatment is …
frequently in younger women than those with high-grade disease. The current treatment is …
Mitochondrial dysfunction decreases cisplatin sensitivity in gastric cancer cells through upregulation of integrated stress response and mitokine GDF15
SF Wang, YL Chang, TY Liu, KH Huang… - The FEBS …, 2024 - Wiley Online Library
Gastric neoplasm is a high‐mortality cancer worldwide. Chemoresistance is the obstacle
against gastric cancer treatment. Mitochondrial dysfunction has been observed to promote …
against gastric cancer treatment. Mitochondrial dysfunction has been observed to promote …
[HTML][HTML] Bioactive hexapeptide reduced the resistance of ovarian cancer cells to DDP by affecting HSF1/HSP70 signaling pathway
R Guo, Q Xu, L Liu, H Liu, Y Liu, W Wei, Y Qin - Journal of Cancer, 2021 - ncbi.nlm.nih.gov
Ovarian cancer is the leading cause of death in gynecologic malignancies. Ovarian cancer
as a metastatic malignant tumor is highly recurrent and prone to drug resistance. Bioactive …
as a metastatic malignant tumor is highly recurrent and prone to drug resistance. Bioactive …
Growth and differentiation factor 15: An emerging therapeutic target for brain diseases
Y Zhou, L Dou, L Wang, J Chen, R Mao, L Zhu… - BioScience …, 2025 - jstage.jst.go.jp
Growth and differentiation factor 15 (GDF15), a member of the transforming growth factor-β
superfamily, is considered a stress response factor and has garnered increasing attention in …
superfamily, is considered a stress response factor and has garnered increasing attention in …
Molecular profiles of predictive biomarkers for platinum-based chemotherapy in Non-Small Cell Lung Cancer (NSCLC)
NT Seyedabadi, SYZ Shoushtari, A Soofi, J Arabpour… - Meta Gene, 2022 - Elsevier
Background Non-small cell lung cancer (NSCLC) is the principal subtype of lung cancer.
Among all therapeutic options, platinum-based chemotherapy agents, especially Cisplatin …
Among all therapeutic options, platinum-based chemotherapy agents, especially Cisplatin …
Identification of new proteins related with cisplatin resistance in Saccharomyces cerevisiae
AM Burgos-Molina, S Mercado-Sáenz… - Applied Microbiology …, 2021 - Springer
The aim of this study is to select a cisplatin-resistant Saccharomyces cerevisiae strain to look
for new molecular markers of resistance and the identification of mechanisms/interactions …
for new molecular markers of resistance and the identification of mechanisms/interactions …
[PDF][PDF] downloaded from the King's Research Portal at https://kclpure. kcl. ac. uk/portal
J Deng - 2023 - kclpure.kcl.ac.uk
Colorectal cancer is the fourth most lethal cancer worldwide. Conventional cytotoxic
chemotherapy is the standard of care treatment for patients with advanced disease. The …
chemotherapy is the standard of care treatment for patients with advanced disease. The …