MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …

The transcription factor p63 is a master regulator of epidermal development. Mutations in
p63 give rise to human developmental diseases that often manifest epidermal defects. In this …

Inflammatory bowel disease (IBD) is a chronic inflammatory condition driven by diverse
genetic and nongenetic programs that converge to disrupt immune homeostasis in the …

The transcription factor p63 plays a pivotal role in keratinocyte proliferation and
differentiation in the epidermis. However, how p63 regulates epidermal genes during …

Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from
various organs. TP63 is a master regulator that plays an essential role in epidermal …

TP53 is commonly altered in human cancer, and Tp53 reactivation suppresses tumours in
vivo in mice,(TP53 and Tp53 are also known as p53). This strategy has proven difficult to …

Although p53 has long been known as the “guardian of the genome” with a role in tumor
suppression in many tissues, the discovery of two p53 ancestral genes, p63 and p73, more …

The p53 family of transcription factors is essential to counteract tumour formation and
progression. Although previously this was exclusively associated with the ability of the p53 …

Asherman's syndrome (AS) is a common disease that presents endometrial regeneration
disorder. However, little is known about its molecular features of this aregenerative …

The lung exhibits a robust, multifaceted regenerative response to severe injuries such as
influenza infection, during which quiescent lung-resident epithelial progenitors participate in …