Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the
human genome, may hold missing drivers of cancer and have gained attention recently as a …

One signal that is overactivated in a wide range of tumour types is the production of a
phospholipid, phosphatidylinositol (3, 4, 5) trisphosphate, by phosphatidylinositol 3-kinase …

Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs)
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …

The programmed cell death that occurs as part of normal mammalian development was first
observed nearly a century ago (Collin 1906). It has since been established that …

Abstract Background The RTK/PI3K/AKT pathway plays key roles in the development and
progression of many cancers, including GBM. As a regulatory molecule and a potential drug …

Targeted therapy with imatinib and other selective tyrosine kinase inhibitors has transformed
the treatment of chronic myeloid leukemia. Unlike chronic myeloid leukemia, chronic …

The mechanistic target of rapamycin, mTOR, controls cell metabolism in response to growth
signals and stress stimuli. The cellular functions of mTOR are mediated by two distinct …

Protein kinase B/Akt regulates cellular metabolism, survival, and proliferation in response to
hormones and growth factors. Hyperactivation of Akt is frequently observed in cancer, while …

The AKT1, AKT2, and AKT3 kinases have emerged as critical mediators of signal
transduction pathways downstream of activated tyrosine kinases and phosphatidylinositol 3 …