Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia
are two types of hypoxia occurring in malignant tumors. They are both associated with the …

Cancer is one of the major causes of death in the world and its global burden is expected to
continue increasing. In several types of cancers, reactive oxygen species (ROS) have been …

The molecular mechanisms that couple glycolysis to cancer drug resistance remain unclear.
Here we identify an ATP-binding motif within the NADPH oxidase isoform, NOX4, and show …

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

M2-type tumor-associated macrophages (TAMs) infiltration contributes to cancer malignant
progression. However, the mechanisms for controlling recruitment and M2 polarization of …

Significance: Reactive oxygen species (ROS) promote genomic instability, altered signal
transduction, and an environment that can sustain tumor formation and growth. The NOX …

The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is
becoming recognized as key modulators of signal transduction pathways with a …

NADPH oxidases (NOX) are reactive oxygen species‐(ROS‐) generating enzymes
regulating numerous redox‐dependent signaling pathways. NOX are important regulators of …

Reactive oxygen species derived from NADPH oxidase contribute to a wide variety of renal
diseases. Nox4, the major NADPH isoform in kidney, produces mainly H 2 O 2 that regulates …

The formation of reactive oxygen species (ROS) by the myeloid cell NADPH oxidase NOX2
is critical for the destruction of engulfed microorganisms. However, recent studies imply that …