RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …

Termini often determine the fate of RNA molecules. In recent years, 3′ ends of almost all
classes of RNA species have been shown to acquire nontemplated nucleotides that are …

Strand selection is a critical step in microRNA (miRNA) biogenesis. Although the dominant
strand may change depending on cellular contexts, the molecular mechanism and …

MicroRNAs (miRNAs) associated with Argonaute proteins (AGOs) regulate gene expression
in mammals. miRNA 3'ends are subject to frequent sequence modifications, which have …

Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that function
in the nucleus. We previously found that erroneous rRNAs induce the generation of …

The RNA exosome is a ribonuclease complex that mediates both RNA processing and
degradation. This complex is evolutionarily conserved, ubiquitously expressed, and required …

Given the complexity of intracellular RNA ensembles and vast phenotypic remodeling
intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory …

Eukaryotic ribosome assembly is a highly orchestrated process that involves over two
hundred protein factors. After early assembly events on nascent rRNA in the nucleolus, pre …

Ribosomes are essential macromolecular machines responsible for translating the genetic
information encoded in mRNAs into proteins. Ribosomes are composed of ribosomal RNAs …

Targeting synthetic lethal interactions among genes has emerged as a promising strategy
for cancer therapy. This study explores the intricate interplay among terminal …