Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review

Y Chen, O Yang, C Sampat, P Bhalode… - Processes, 2020 - mdpi.com
The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

Bioprocessing in the digital age: the role of process models

H Narayanan, MF Luna, M von Stosch… - Biotechnology …, 2020 - Wiley Online Library
In this age of technology, the vision of manufacturing industries built of smart factories is not
a farfetched future. As a prerequisite for Industry 4.0, industrial sectors are moving towards …

Machine learning for biologics: opportunities for protein engineering, developability, and formulation

H Narayanan, F Dingfelder, A Butté, N Lorenzen… - Trends in …, 2021 - cell.com
Successful biologics must satisfy multiple properties including activity and particular
physicochemical features that are globally defined as developability. These multiple …

Bioprocess control: current progress and future perspectives

AS Rathore, S Mishra, S Nikita, P Priyanka - Life, 2021 - mdpi.com
Typical bioprocess comprises of different unit operations wherein a near optimal
environment is required for cells to grow, divide, and synthesize the desired product …

Advancements in SPR biosensing technology: An overview of recent trends in smart layers design, multiplexing concepts, continuous monitoring and in vivo sensing

JH Qu, A Dillen, W Saeys, J Lammertyn, D Spasic - Analytica chimica acta, 2020 - Elsevier
Inspired by the rapid progress and existing limitations in surface plasmon resonance (SPR)
biosensing technology, we have summarized the recent trends in the fields of both chip-SPR …

Biopharmaceutical manufacturing: Historical perspectives and future directions

AC Szkodny, KH Lee - Annual Review of Chemical and …, 2022 - annualreviews.org
This review describes key milestones related to the production of biopharmaceuticals—
therapies manufactured using recombinant DNA technology. The market for …

Process analytical technologies and data analytics for the manufacture of monoclonal antibodies

MK Maruthamuthu, SR Rudge, AM Ardekani… - Trends in …, 2020 - cell.com
Process analytical technology (PAT) for the manufacture of monoclonal antibodies (mAbs) is
defined by an integrated set of advanced and automated methods that analyze the …

Bioprocess systems analysis, modeling, estimation, and control

Y Luo, V Kurian, BA Ogunnaike - Current Opinion in Chemical Engineering, 2021 - Elsevier
The production of monoclonal antibody (mAb) therapeutics, a rapidly growing multi-billion-
dollar enterprise in the biopharmaceutical industry, faces major challenges in achieving …

Recent trends in AI-based intelligent sensing

A Sharma, V Sharma, M Jaiswal, HC Wang… - Electronics, 2022 - mdpi.com
In recent years, intelligent sensing has gained significant attention because of its
autonomous decision-making ability to solve complex problems. Today, smart sensors …

Recent advances in integrated process analytical techniques, modeling, and control strategies to enable continuous biomanufacturing of monoclonal antibodies

V Chopda, A Gyorgypal, O Yang… - Journal of Chemical …, 2022 - Wiley Online Library
Continuous bioprocessing is significantly changing the biological drugs (or biologics)
manufacturing landscape by potentially improving product quality, process stability, and …