Depression is linked to deficits in cognitive control and a host of other cognitive impairments
arise as a consequence of these deficits. Despite of their important role in depression, there …

How is the massive dimensionality and complexity of the microscopic constituents of the
nervous system brought under sufficiently tight control so as to coordinate adaptive …

The human brain is a complex, adaptive system comprised of billions of cells with trillions of
connections. The interactions between the elements of the system oppose this seemingly …

Optogenetic stimulation of Adora2a receptor-expressing spiny projection neurons (A2A-
SPNs) in the striatum drives locomotor suppression and transient punishment, results …

Response inhibition is an important component of adaptive behavior. Substantial prior
research has focused on reactive inhibition, which refers to the cessation of a motor …

A neural pathway from prefrontal cortex (PFC) to dorsal striatum (DS) has been suggested to
mediate cognitive control of behavior, including proactive inhibitory control and attention …

Dopamine agonists (DAs) have demonstrated efficacy for the treatment of Parkinson's
disease (PD) but are limited by adverse effects (AEs). DAs can vary considerably in their …

Interactive behaviors rely on the operation of several processes allowing the control of
actions, including their selection, withholding, and cancellation. The corticospinal system …

The flexibility of behavioral control is a testament to the brain's capacity for dynamically
resolving uncertainty during goal-directed actions. This ability to select actions and learn …

We developed a circuit model of spiking neurons that includes multiple pathways in the
basal ganglia (BG) and is endowed with feedback mechanisms at three levels: cortical …