Synaptic plasticity in the mammalian central nervous system has been the subject of intense
investigation for the past four decades. Long-term potentiation (LTP), a major reflection of …

This review will provide an overview of the non-drug based approaches that have been
demonstrated to enhance cognitive function of the compromised brain, primarily focussed on …

The oxytocinergic system promotes social behavior and reduces anxiety. The significant
roles and functional interactions of the medial prefrontal cortex and the amygdala in the …

The neural circuit linking the medial prefrontal cortex (mPFC) and the basolateral amygdala
(BLA) has crucial roles in both the acquisition and the extinction of fear. However, the …

This study addressed the question of whether extinction in pairs would have a beneficial
effect on extinction of fear conditioning. To that end, we established an experimental setting …

Long-term memory is supported not only by modulation of synaptic strength, but also by
modifications in intrinsic neuronal properties. Learning-induced enhancement of neuronal …

Background: Cognitive behavioral therapy (CBT) is an effective treatment for panic disorder
with agoraphobia (PD/AG). It is unknown, how variants of CBT differentially modulate brain …

A growing body of evidence suggests that the hypothalamic neuropeptide oxytocin (OT),
aside from its central role in the regulation of social behavior, reduces fear and anxiety. The …

Medial prefrontal circuits have been reported to undergo a major reorganization over time
and gradually take a more important role for remote emotional memories such as contextual …

We previously reported that in the adult animal extinction in pairs resulted in enhanced
extinction, showing that social presence can reduce previously acquired fear responses …