Treg cell-based therapies: challenges and perspectives
Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …
Multiple sclerosis pathology
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS), which gives rise to focal lesions in the gray and white matter and to …
nervous system (CNS), which gives rise to focal lesions in the gray and white matter and to …
Memory B cells activate brain-homing, autoreactive CD4+ T cells in multiple sclerosis
Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic,
particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic …
particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic …
[HTML][HTML] Androgen-induced immunosuppression
In addition to determining biological sex, sex hormones are known to influence health and
disease via regulation of immune cell activities and modulation of target-organ susceptibility …
disease via regulation of immune cell activities and modulation of target-organ susceptibility …
Determinants and biomarkers of progression independent of relapses in multiple sclerosis
Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a
smoldering inflammatory activity is present from the earliest stages of the disease and …
smoldering inflammatory activity is present from the earliest stages of the disease and …
HLA-DR15 molecules jointly shape an autoreactive T cell repertoire in multiple sclerosis
The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but
our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …
our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …
The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis
Neuroinflammation is the coordinated response of the central nervous system (CNS) to
threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens …
threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens …
Monocyte recruitment during infection and inflammation
Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to
peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave …
peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave …
CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation
The relevance of regulatory B cells in the maintenance of tolerance in healthy individuals or
in patients with immune disorders remains understudied. In healthy individuals, CD19+ …
in patients with immune disorders remains understudied. In healthy individuals, CD19+ …
CXCR3 in T cell function
CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …