Alzheimer's disease (AD) is characterized pathologically by the deposition of β-amyloid
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …

Astrocytes, the most numerous glial cells in the brain, play an important role in preserving
normal neural functions and mediating the pathogenesis of neurological disorders. Recent …

Astrocytes are ideally placed to detect and respond to network activity. They express
ionotropic and metabotropic receptors, and can release gliotransmitters. Astrocytes also …

Circadian disruption has become more prevalent in society due to the increase in shift work,
sleep disruption, blue light exposure, and travel via different time zones. The circadian …

Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to
be synthesized and released from GABAergic neurons in the brain. However, recent studies …

The circadian clock is an endogenous, time-tracking system that directs multiple metabolic
and physiological functions required for homeostasis. The master or central clock located …

Therapeutics discovery and development for Alzheimer's disease (AD) has been an area of
intense research to alleviate memory loss and the underlying pathogenic processes. Recent …

The extracellular concentration of the two main neurotransmitters glutamate and GABA is
low but not negligible which enables a number of tonic actions. The effects of ambient GABA …

Major depressive disorder (MDD) is a form of glial cell-based synaptic dysfunction disease
in which glial cells interact closely with neuronal synapses and perform synaptic information …

General anesthetic drugs cause cognitive deficits that persist after the drugs have been
eliminated. Astrocytes may contribute to such cognition-impairing effects through the release …