Amino acid metabolism plays important roles in tumor biology and tumor therapy.
Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor …

Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …

Human uptake abundance of microplastics via various pathways, and they accumulate in
human liver, kidney, gut and even placenta (especially with a diameter of 1 μm or less) …

Glutamine, the most abundant free amino acid in the human body, is a major substrate
utilized by intestinal cells. The roles of glutamine in intestinal physiology and management …

Detailed studies in the past two decades have shown that redox active metals like iron (Fe),
copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions …

Acute kidney injury (AKI) represents a common complication in critically ill patients that is
associated with increased morbidity and mortality. In a murine AKI model induced by …

We identified a p53 target gene, phosphate-activated mitochondrial glutaminase (GLS2), a
key enzyme in conversion of glutamine to glutamate, and thereby a regulator of glutathione …

Cancer cell metabolism including aerobic glycolysis, amino acid and fatty acid metabolism,
has been extensively studied. Metabolic reprogramming is a major hallmark of cancer …

The intestinal barrier integrity is essential for the absorption of nutrients and health in
humans and animals. Dysfunction of the mucosal barrier is associated with increased gut …

Epigenetic regulation established during development to maintain patterns of transcriptional
expression and silencing for metabolism and other fundamental cell processes can be …