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Silencing neurons: tools, applications, and experimental constraints
Reversible silencing of neuronal activity is a powerful approach for isolating the roles of
specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal …
specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal …
Filopodia: molecular architecture and cellular functions
Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for
cells to probe their environment. Consequently, filopodia have an important role in cell …
cells to probe their environment. Consequently, filopodia have an important role in cell …
Incorporating neuro-inspired adaptability for continual learning in artificial intelligence
Continual learning aims to empower artificial intelligence with strong adaptability to the real
world. For this purpose, a desirable solution should properly balance memory stability with …
world. For this purpose, a desirable solution should properly balance memory stability with …
Labelling and optical erasure of synaptic memory traces in the motor cortex
Dendritic spines are the major loci of synaptic plasticity and are considered as possible
structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of …
structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of …
Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
Major depressive disorder is associated with abnormalities in the brain and the immune
system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms …
system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms …
Mammalian Rho GTPases: new insights into their functions from in vivo studies
SJ Heasman, AJ Ridley - Nature reviews Molecular cell biology, 2008 - nature.com
Rho GTPases are key regulators of cytoskeletal dynamics and affect many cellular
processes, including cell polarity, migration, vesicle trafficking and cytokinesis. These …
processes, including cell polarity, migration, vesicle trafficking and cytokinesis. These …
Dentritic spines: structure, dynamics and regulation
Dendritic spines are tiny protrusions that receive excitatory synaptic input and
compartmentalize postsynaptic responses. Heterogeneous in size and shape, and …
compartmentalize postsynaptic responses. Heterogeneous in size and shape, and …
Rho GTPases and signaling networks
The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …
proteins that have been shown to regulate a wide spectrum of cellular functions. These …
Near‐infrared optogenetic genome engineering based on photon‐upconversion hydrogels
Photon upconversion (UC) from near‐infrared (NIR) light to visible light has enabled
optogenetic manipulations in deep tissues. However, materials for NIR optogenetics have …
optogenetic manipulations in deep tissues. However, materials for NIR optogenetics have …
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch
A Schmidt, A Hall - Genes & development, 2002 - genesdev.cshlp.org
Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …