Astragaloside IV inhibits retinal pigment epithelial cell senescence and reduces IL-1β mRNA stability by targeting FTO-mediated m6A methylation

S Wang, P Li, S Liu, D Huang, S Zhang, X Zeng, T Lan… - Phytomedicine, 2025 - Elsevier
Background Resistance to senescence in retinal pigment epithelial (RPE) cells can delay
the progression of age-related macular degeneration (AMD). However, the mechanisms …

[HTML][HTML] S6K1 Controls DNA Damage Signaling Modulated by the MRN Complex to Induce Radioresistance in Lung Cancer

A Calderon-Aparicio, J He, NL Simone - International Journal of …, 2024 - mdpi.com
Radiation is a mainstay of lung cancer treatment; however, resistance frequently develops.
Identifying novel therapeutic targets to increase radiation sensitivity is crucial. S6K1 is a …

The S6 kinase gene in the fruit fly, Drosophila melanogaster, is essential for metabolic regulation

JP Álvarez-Rendón, JR Riesgo-Escovar - General and Comparative …, 2025 - Elsevier
Abstract The S6 kinase (S6K) enzyme phosphorylates the S6 ribosomal protein, promoting
protein translation and growth. Here we investigated in flies whether hypomorphic …