Ascorbic acid (vitamin C) is an unusual antioxidant in that it donates a single reducing
equivalent, and the radical it forms, monodehydroascorbate, reacts preferentially with …

Increasing numbers of individuals suffer from neurodegenerative diseases, which are
characterized by progressive loss of neurons. Oxidative stress, in particular, the …

Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Iron, the fourth most abundant element in the Earth's crust, is vital in living organisms
because of its diverse ligand-binding and electron-transfer properties. This ability of iron in …

Ascorbic acid is among the most abundant antioxidants in the lung, where it likely plays a
key role in the mechanism by which particulate air pollution initiates a biological response …

The main molecular mechanisms explaining the well-established antioxidant and reducing
activity of N-acetylcysteine (NAC), the N-acetyl derivative of the natural amino acid l …

Ascorbic acid is synthesised by eukaryotes, the known exceptions being primates and some
other animal groups which have lost functional gulonolactone oxidase. Prokaryotes do not …

Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …

Remarkable interest has risen in the idea that oxidative/nitrosative stress is mediated in the
etiology of numerous human diseases. Oxidative/Nitrosative stress is the result of an …

Enzymes currently known as lytic polysaccharide monooxygenases (LPMOs) play an
important role in the conversion of recalcitrant polysaccharides, but their mode of action has …