Introduction Low dosages of aspirin [1, 2] and ingestion of certain fish oils [3-6] have recently
been touted as having some value in preventing cardiovascular disease. Aspirin is a …

The existence of enzymes catalyzing tile release of fatty acids from phospholipids was
proposed over a hundred years ago, when it was observed that incubation of …

Exposure of phospholipids at the outer surface of activated and control platelets was studied
by incubation with a mixture of phospholipase A 2 from Naja naja and bee venom, solely or …

Aggregation of human platelets induced by a variety of agonists was inhibited by 1-[6-[[17
beta-3-methoxyestra-1, 3, 5 (10)-trien-17-yl] amino] hexyl]-1H-pyrrole-2, 5-dionel (U …

We describe the enzymological regulation of the formation of prostaglandin (PG) D 2, PGE 2,
PGF 2α, 9α, 11β-PGF 2, PGI 2 (prostacyclin), and thromboxane (Tx) A 2 from arachidonic …

PLATELETS CIRCULATE passively as they traverse the vascular tree that is lined by an
intact monolayer of endothelial cells. In response to vessel wall injury or exposure to foreign …

Platelets, when stirred with 3 U thrombin/10 9 platelets, produced significant quantities of
palmitoyllysophosphatidic acid (2.17 ng/10 9 platelets), stearoyllysophosphatidic acid (2.11 …

Chapters 6–8 covered the mammalian phospholipases that are cellular for the most part.
This chapter and the following chapters also include some mammalian phospholipases A 2; …

Endogenous phospholipid metabolism in stimulated human platelets was studied by
phosphorus assay of major and minor components following separation by two-dimensional …

Deoxycholate treatment of horse platelets previously labeled in their phospholipids with
[14C] arachidonate produces selective conversion of [14C] phosphatidylinositol (PI) to [14C] …