Past antihypertensive medication use is associated with lower levels of small vessel disease and lower Aβ plaque stage in the brains of older individuals

AJ Affleck, PS Sachdev… - … and Applied Neurobiology, 2023‏ - Wiley Online Library
Aims This study assesses the association of antihypertensive medication use on the
severities of neuropathological cerebrovascular disease (CVD excluding lobar infarction) in …

AD and its comorbidities: An obstacle to develop a clinically efficient treatment?

J Baker, JM Schott - Revue Neurologique, 2022‏ - Elsevier
Whilst the development of new drugs designed for the treatment of Alzheimer's disease (AD)
has been widely publicised, we do not yet have treatments that are proven to slow the …

Histopathological analysis of cerebrovascular lesions associated with aging

C Dallaire-Théroux, S Saikali, M Richer… - … of Neuropathology & …, 2022‏ - academic.oup.com
Cerebrovascular disease (CVD) has been associated with cognitive impairment. Yet, our
understanding of vascular contribution to cognitive decline has been limited by …

Association between behavioral and psychological symptoms and cerebral small vessel disease MRI findings in memory clinic patients

M Shinohara, K Matsuda, Y Ii, K Tabei… - Frontiers in aging …, 2023‏ - frontiersin.org
Objectives Cerebral small vessel disease (SVD) is commonly observed among elderly
individuals with cognitive impairment and has been recognized as a vascular contributor to …

Comorbid neuropathology and atypical presentation of Alzheimer's disease

SD Pina‐Escudero, R La Joie, S Spina… - Alzheimer's & …, 2024‏ - Wiley Online Library
INTRODUCTION Alzheimer's disease (AD) neuropathological changes present with
amnestic and nonamnestic (atypical) syndromes. The contribution of comorbid …

[HTML][HTML] Mitigation of Atherosclerotic Vascular Damage and Cognitive Improvement Through Mesenchymal Stem Cells in an Alzheimer's Disease Mouse Model

WJ Lee, KJ Cho, GW Kim - International Journal of Molecular Sciences, 2024‏ - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative condition characterized by progressive
memory loss and other cognitive disturbances. Patients with AD can be vulnerable to …

A pilot randomized controlled trial of WeiNaoKang (SaiLuoTong) in treating vascular dementia

J Liu, D Chang, D Cordato, K Lee, H Dixson… - Aging …, 2022‏ - Wiley Online Library
Abstract Objective WeiNaoKang (or SaiLuoTong) is an herbal formula consisting of ginkgo,
ginseng, and saffron. Our objective was to investigate if WeiNaoKang could improve …

Comorbid amyloid with cerebrovascular disease in domain-specific cognitive and neuropsychiatric disturbances: a cross-sectional memory clinic study

CN Kan, X Huang, L Zhang, S Hilal, A Reilhac… - Neurobiology of …, 2023‏ - Elsevier
Dementia is a multifactorial disorder that is likely influenced by both Alzheimer's disease
(AD) and vascular pathologies. We evaluated domain-specific cognitive and …

Biological validation of peak‐width of skeletonized mean diffusivity as a VCID biomarker: The MarkVCID Consortium

AM Luckey, S Ghosh, CP Wang, A Beiser… - Alzheimer's & …, 2024‏ - Wiley Online Library
BACKGROUND Peak‐width of skeletonized mean diffusivity (PSMD), a neuroimaging
marker of cerebral small vessel disease (SVD), has shown excellent instrumental properties …

Utility of cerebrovascular imaging biomarkers to detect cerebral amyloidosis

MD Howe, MR Caruso, M Manoochehri… - Alzheimer's & …, 2024‏ - Wiley Online Library
INTRODUCTION The relationship between cerebrovascular disease (CVD) and amyloid
beta (Aβ) in Alzheimer's disease (AD) is understudied. We hypothesized that magnetic …