The mammalian heart is responsible for not only pum** blood throughout the body but
also adjusting this pum** activity quickly depending upon sudden changes in the …

Cardiac optical map** has proven to be a powerful technology for studying cardiovascular
function and disease. The development and scientific impact of this methodology are well …

Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …

Abstract Cardiac digital twins (Cardiac Digital Twin (CDT) s) of human electrophysiology
(Electrophysiology (EP)) are digital replicas of patient hearts derived from clinical data that …

Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes
(hiPSC-CMs) for drug development and disease modeling studies, methods to generate …

Despite the significant decline in coronary artery disease (CAD) mortality in the second half
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 …

Ventricular arrhythmias are among the most severe complications of heart disease and can
result in sudden cardiac death. Patients at risk currently receive implantable defibrillators …

Neuronal elements distributed throughout the cardiac nervous system, from the level of the
insular cortex to the intrinsic cardiac nervous system, are in constant communication with …

The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …

A long-sought, and thus far elusive, goal has been to develop drugs to manage diseases of
excitability. One such disease that affects millions each year is cardiac arrhythmia, which …