Paralog-based synthetic lethality: rationales and applications
Y ** in prostate cancer using multi-omics approaches
N Gómez-Cebrián, JL Poveda, A Pineda-Lucena… - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer (PCa) is a hormone-dependent tumor characterized by a
highly heterogeneous clinical outcome. This neoplastic process has become a leading …
highly heterogeneous clinical outcome. This neoplastic process has become a leading …
[HTML][HTML] Exosomal transfer leads to chemoresistance through oxidative phosphorylation-mediated stemness phenotype in colorectal cancer
Background: Recently years have seen the increasing evidence identifying that OXPHOS is
involved in different processes of tumor progression and metastasis and has been proposed …
involved in different processes of tumor progression and metastasis and has been proposed …
Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations
Targeting the distinct metabolic needs of tumor cells has recently emerged as a promising
strategy for cancer therapy. The heterogeneous, context-dependent nature of cancer cell …
strategy for cancer therapy. The heterogeneous, context-dependent nature of cancer cell …
A human metabolic map of pharmacological perturbations reveals drug modes of action
L Schuhknecht, K Ortmayr, J Jänes, M Bläsi… - Nature …, 2025 - nature.com
Understanding a small molecule's mode of action (MoA) is essential to guide the selection,
optimization and clinical development of lead compounds. In this study, we used high …
optimization and clinical development of lead compounds. In this study, we used high …
Phytotherapeutic approaches to the prevention of age-related changes and the extension of active longevity
O Babich, V Larina, S Ivanova, A Tarasov, M Povydysh… - Molecules, 2022 - mdpi.com
Maintaining quality of life with an increase in life expectancy is considered one of the global
problems of our time. This review explores the possibility of using natural plant compounds …
problems of our time. This review explores the possibility of using natural plant compounds …
Establishment and validation of a carbohydrate metabolism-related gene signature for prognostic model and immune response in acute myeloid leukemia
Y Yang, Y Yang, J Liu, Y Zeng, Q Guo, J Guo… - Frontiers in …, 2022 - frontiersin.org
Introduction The heterogeneity of treatment response in acute myeloid leukemia (AML)
patients poses great challenges for risk scoring and treatment stratification. Carbohydrate …
patients poses great challenges for risk scoring and treatment stratification. Carbohydrate …
Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states
Metabolism negotiates cell-endogenous requirements of energy, nutrients and building
blocks with the immediate environment to enable various processes, including growth and …
blocks with the immediate environment to enable various processes, including growth and …
Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells
P Athanasiadis, B Ravikumar, RJR Elliott, JC Dawson… - Iscience, 2023 - cell.com
Designing a targeted screening library of bioactive small molecules is a challenging task
since most compounds modulate their effects through multiple protein targets with varying …
since most compounds modulate their effects through multiple protein targets with varying …
A Combinatorial Functional Precision Medicine Platform for Rapid Therapeutic Response Prediction in AML
NRBM Sahib, JS Mohamed, MBMA Rashid… - Cancer …, 2024 - Wiley Online Library
Background Despite advances made in targeted biomarker‐based therapy for acute myeloid
leukemia (AML) treatment, remission is often short and followed by relapse and acquired …
leukemia (AML) treatment, remission is often short and followed by relapse and acquired …