Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a
central role in obesity-related diseases, including insulin resistance/type 2 diabetes and …

Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in
diabetic patients. This should have been an important clue to link inflammation to the …

Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2
diabetes. Here we show how the human gut microbiome impacts the serum metabolome …

While modernization has dramatically increased lifespan, it has also witnessed the
increasing prevalence of diseases such as obesity, hypertension, and type 2 diabetes. Such …

Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid
(BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and …

It has become increasingly difficult to find an area of cell biology in which lipids do not have
important, if not key, roles as signalling and regulatory molecules. The rapidly expanding …

Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue
releases a large number of bioactive mediators that influence not only body weight …

There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

Abstract The “metabolic syndrome”(MetS) is a clustering of components that reflect
overnutrition, sedentary lifestyles, and resultant excess adiposity. The MetS includes the …

Weight gain and obesity are major risk factors for conditions and diseases ranging from
insulin resistance and type 2 diabetes mellitus to atherosclerosis and the sequelae of …