G protein-coupled receptors (GPCRs) mediate physiological responses to various ligands,
such as hormones, neurotransmitters and sensory stimuli. The signalling and trafficking …

G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …

The melanocortin peptides derived from pro-opiomelanocortin (POMC) were originally
understood in terms of the biological actions of α-melanocyte-stimulating hormone (α-MSH) …

The melanocortin receptor (MCR) family consists of 5 G protein-coupled receptors (MC1R–
MC5R) with diverse physiologic roles. MC2R is a critical component of the hypothalamic …

The transmembrane enzyme CD38, a multifunctional protein ubiquitously present in cells, is
the main enzyme that synthesizes and hydrolyzes cyclic adenosine 5′-diphosphate-ribose …

Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP)
are two structurally distinct messengers that mobilize the endoplasmic and endolysosomal …

G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma
membrane seven times (hence, are also called 7TM receptors). The polytopic structure of …

The melanocortin-4 receptor (MC4R) is essential for control of energy homeostasis in
vertebrates. MC4R interacts with melanocortin receptor accessory protein 2 (MRAP2) in …

G protein-coupled receptors (GPCRs) are regulated by various downstream proteins, of
which the melanocortin receptor accessory protein 1 (MRAP1) is closely involved in the …

Coincidentally, the release of this Research Topic in Frontiers in Endocrinology takes place
25 years after the discovery of the adrenocorticotropic hormone receptor (ACTHR) by …