Objectives This review examines the pharmacokinetics, modes of action and therapeutic
properties of the anti-malarial drugs, hydroxychloroquine (HCQ) and chloroquine (CQ), in …

The association between hyperglycemia and inflammation and vascular complications in
diabetes is now well established. Antidiabetes drugs may alleviate inflammation by reducing …

Objective Cardiovascular disease (CVD) is the leading cause of mortality in patients with
rheumatoid arthritis (RA). Hydroxychloroquine (HCQ) has been shown to improve survival …

ContextHydroxychloroquine, a commonly used antirheumatic medication, has hypoglycemic
effects and may reduce the risk of diabetes mellitus. ObjectiveTo determine the association …

Aim: To assess the glucose-lowering efficacy, responsiveness, duration of action and impact
on quality-of-life of hydroxychloroquine (HXCHL), when added as an antihyperglycemic …

Hydroxychloroquine (HCQ), a commonly used antimalarial drug in rheumatic diseases, has
shown favorable metabolic effects on both glucose control and lipid profiles. We describe a …

Objective: To compare efficacy and safety of hydroxychloroquine with pioglitazone in type 2
diabetes mellitus (T2DM). Research design and methods: This double-blind study …

DNA damage accumulates with age (Lombard et al., 2005). However, whether and how
robust DNA repair machinery promotes longevity is elusive. Here, we demonstrate that ATM …

OBJECTIVE Innate immune responses may be involved in the earliest phases of type 1
diabetes (T1D). RESEARCH DESIGN AND METHODS To test whether blocking innate …

Due to multiple beneficial effects, including control of disease activity, reduction in
cardiovascular events and improved survival, hydroxychloroquine is now recommended …