The synthetic dye malachite green found in food induces cytotoxicity and genotoxicity in four different mammalian cell lines from distinct tissuesw

AO de Almada Vilhena, KMM Lima… - Toxicology …, 2023 - academic.oup.com
Malachite green (MG) is a synthetic dye that uses ranges from its application as a tissue dye
to that as an antiparasitic in aquaculture. Several studies have reported the presence of this …

Metal coordination and biological screening of a Schiff Base derived from 8-hydroxyquinoline and benzothiazole

N Ribeiro, PF Farinha, JO Pinho, H Luiz, JP Mészáros… - Pharmaceutics, 2022 - mdpi.com
Designing new metallodrugs for anticancer therapy is a driving force in the scientific
community. Aiming to contribute to this field, we hereby report the development of a Schiff …

Mebendazole targets essential proteins in glucose metabolism leading gastric cancer cells to death

EL da Silva, FP Mesquita, DR Aragão… - Toxicology and Applied …, 2023 - Elsevier
Gastric cancer (GC) is among the most-diagnosed and deadly malignancies worldwide.
Deregulation in cellular bioenergetics is a hallmark of cancer. Based on the importance of …

Synthetic Peptides Induce Human Colorectal Cancer Cell Death via Proapoptotic Pathways

FP Mesquita, FL de Oliveira, EL da Silva, DMS Brito… - ACS …, 2024 - ACS Publications
Cancer resistance to drugs and chemotherapy is a problem faced by public health systems
worldwide. Repositioning antimicrobial peptides could be an efficient strategy to overcome …

MAPK14 (p38α) inhibition effects against metastatic gastric cancer cells: A potential biomarker and pharmacological target

FP Mesquita, CA Moreira-Nunes, EL da Silva, LB Lima… - Toxicology in Vitro, 2020 - Elsevier
Gastric cancer has been considering one of the worst cancer types since it is diagnosed in
advanced stages, currently in the metastatic stage. Therefore, the challenge is to find out a …

Antitumoral effect of novel synthetic 8-hydroxy-2-((4-nitrophenyl) thio) naphthalene-1, 4-dione (CNN16) via ROS-mediated DNA damage, apoptosis and anti-migratory …

EL da Silva, FP Mesquita, IN de Farias Ramos… - Toxicology and Applied …, 2022 - Elsevier
Colorectal cancer (CRC) is estimated as the third most incident cancer and second in
mortality worldwide. Moreover, CRC metastasis reduces patients' survival rates. Thus, the …

Versatile coordination modes of benzothiazole hydrazone derivatives towards Ru (II), Rh (III) and Ir (III) complexes and their reactivity studies with azides and activated …

L Dkhar, W Kaminsky, KM Poluri… - Journal of Organometallic …, 2019 - Elsevier
Metal precursors of the type [(p-cymene) RuCl 2] 2 and [Cp* MCl 2] 2 (M= Rh/Ir) on reacting
with benzothiazole hydrazones ligands (L1= benzylidenehydrazinyl benzothiazole, L2= 4 …

[HTML][HTML] Knockdown of MSI1 inhibits the proliferation of human oral squamous cell carcinoma by inactivating STAT3 signaling

CF Wang, HC Zhang, XM Feng… - International …, 2019 - spandidos-publications.com
Musashi RNA‑binding protein 1 (MSI1) is highly expressed in several types of cancer;
however, its role in oral squamous cell carcinoma (OSCC) remains unknown. The purpose …

Kinase inhibitor screening reveals aurora‐a kinase is a potential therapeutic and prognostic biomarker of gastric cancer

FP Mesquita, E Lucena da Silva… - Journal of Cellular …, 2021 - Wiley Online Library
Gastric cancer is one of the most common and deadly types of cancer in the world, and poor
prognosis with treatment failure is widely reported in the literature. In this context, kinases …

Differences in glucose concentration shows new perspectives in gastric cancer metabolism

EL da Silva, FP Mesquita, AJ de Sousa Portilho… - Toxicology in Vitro, 2022 - Elsevier
Gastric cancer (GC) is among the deadliest cancers worldwide despite available therapies,
highlighting the need for novel therapies and pharmacological agents. Metabolic …