Treating bacterial infections with bacteriophage-based enzybiotics: in vitro, in vivo and clinical application
Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …
The preclinical and clinical progress of bacteriophages and their lytic enzymes: the parts are easier than the whole
The therapeutic potential of phages has been considered since their first identification more
than a century ago. The evident concept of using a natural predator to treat bacterial …
than a century ago. The evident concept of using a natural predator to treat bacterial …
Pseudomonas predators: understanding and exploiting phage–host interactions
Species in the genus Pseudomonas thrive in a diverse set of ecological niches and include
crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant …
crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant …
Exploring the synthetic biology potential of bacteriophages for engineering non-model bacteria
Non-model bacteria like Pseudomonas putida, Lactococcus lactis and other species have
unique and versatile metabolisms, offering unique opportunities for Synthetic Biology …
unique and versatile metabolisms, offering unique opportunities for Synthetic Biology …
High coverage metabolomics analysis reveals phage-specific alterations to Pseudomonas aeruginosa physiology during infection
Phage-mediated metabolic changes in bacteria are hypothesized to markedly alter global
nutrient and biogeochemical cycles. Despite their theoretic importance, experimental data …
nutrient and biogeochemical cycles. Despite their theoretic importance, experimental data …
Metabolic reprogramming of Pseudomonas aeruginosa by phage-based quorum sensing modulation
H Hendrix, M Zimmermann-Kogadeeva… - Cell Reports, 2022 - cell.com
The Pseudomonas quinolone signal (PQS) is a multifunctional quorum sensing molecule of
key importance to P. aeruginosa. Here, we report that the lytic Pseudomonas bacterial virus …
key importance to P. aeruginosa. Here, we report that the lytic Pseudomonas bacterial virus …
Next-Generation “-omics” Approaches Reveal a Massive Alteration of Host RNA Metabolism during Bacteriophage Infection of Pseudomonas aeruginosa
As interest in the therapeutic and biotechnological potentials of bacteriophages has grown,
so has value in understanding their basic biology. However, detailed knowledge of infection …
so has value in understanding their basic biology. However, detailed knowledge of infection …
Functional polyamine metabolic enzymes and pathways encoded by the virosphere
B Li, J Liang, HR Baniasadi… - Proceedings of the …, 2023 - National Acad Sciences
Viruses produce more viruses by manipulating the metabolic and replication systems of their
host cells. Many have acquired metabolic genes from ancestral hosts and use the encoded …
host cells. Many have acquired metabolic genes from ancestral hosts and use the encoded …
Polyamines and linear DNA mediate bacterial threat assessment of bacteriophage infection
Monitoring the extracellular environment for danger signals is a critical aspect of cellular
survival. However, the danger signals released by dying bacteria and the mechanisms …
survival. However, the danger signals released by dying bacteria and the mechanisms …
The potential of bacteriophages to control Xanthomonas campestris pv. campestris at different stages of disease development
D Holtappels, KJ Fortuna, L Moons… - Microbial …, 2022 - Wiley Online Library
Xanthomonas campestris pv. campestris (Xcc) is a vascular pathogen that invades the xylem
of Brassica crops. Current chemical and antibiotics‐based control measures for this …
of Brassica crops. Current chemical and antibiotics‐based control measures for this …