Treating bacterial infections with bacteriophage-based enzybiotics: in vitro, in vivo and clinical application

KM Danis-Wlodarczyk, DJ Wozniak, ST Abedon - Antibiotics, 2021 - mdpi.com
Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …

The preclinical and clinical progress of bacteriophages and their lytic enzymes: the parts are easier than the whole

K Abdelkader, H Gerstmans, A Saafan, T Dishisha… - Viruses, 2019 - mdpi.com
The therapeutic potential of phages has been considered since their first identification more
than a century ago. The evident concept of using a natural predator to treat bacterial …

Pseudomonas predators: understanding and exploiting phage–host interactions

J De Smet, H Hendrix, BG Blasdel… - Nature Reviews …, 2017 - nature.com
Species in the genus Pseudomonas thrive in a diverse set of ecological niches and include
crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant …

Exploring the synthetic biology potential of bacteriophages for engineering non-model bacteria

EM Lammens, PI Nikel, R Lavigne - Nature communications, 2020 - nature.com
Non-model bacteria like Pseudomonas putida, Lactococcus lactis and other species have
unique and versatile metabolisms, offering unique opportunities for Synthetic Biology …

High coverage metabolomics analysis reveals phage-specific alterations to Pseudomonas aeruginosa physiology during infection

J De Smet, M Zimmermann, M Kogadeeva… - The ISME …, 2016 - academic.oup.com
Phage-mediated metabolic changes in bacteria are hypothesized to markedly alter global
nutrient and biogeochemical cycles. Despite their theoretic importance, experimental data …

Metabolic reprogramming of Pseudomonas aeruginosa by phage-based quorum sensing modulation

H Hendrix, M Zimmermann-Kogadeeva… - Cell Reports, 2022 - cell.com
The Pseudomonas quinolone signal (PQS) is a multifunctional quorum sensing molecule of
key importance to P. aeruginosa. Here, we report that the lytic Pseudomonas bacterial virus …

Next-Generation “-omics” Approaches Reveal a Massive Alteration of Host RNA Metabolism during Bacteriophage Infection of Pseudomonas aeruginosa

A Chevallereau, BG Blasdel, J De Smet, M Monot… - PLoS …, 2016 - journals.plos.org
As interest in the therapeutic and biotechnological potentials of bacteriophages has grown,
so has value in understanding their basic biology. However, detailed knowledge of infection …

Functional polyamine metabolic enzymes and pathways encoded by the virosphere

B Li, J Liang, HR Baniasadi… - Proceedings of the …, 2023 - National Acad Sciences
Viruses produce more viruses by manipulating the metabolic and replication systems of their
host cells. Many have acquired metabolic genes from ancestral hosts and use the encoded …

Polyamines and linear DNA mediate bacterial threat assessment of bacteriophage infection

CD de Mattos, DR Faith, AA Nemudryi… - Proceedings of the …, 2023 - National Acad Sciences
Monitoring the extracellular environment for danger signals is a critical aspect of cellular
survival. However, the danger signals released by dying bacteria and the mechanisms …

The potential of bacteriophages to control Xanthomonas campestris pv. campestris at different stages of disease development

D Holtappels, KJ Fortuna, L Moons… - Microbial …, 2022 - Wiley Online Library
Xanthomonas campestris pv. campestris (Xcc) is a vascular pathogen that invades the xylem
of Brassica crops. Current chemical and antibiotics‐based control measures for this …